Thrombolytic therapy in patients with acute myocardial infarction

被引：0

作者：

不详

机构：

来源：

RATIONAL PHARMACOTHERAPY IN CARDIOLOGY | 2006年 / 2卷 / 04期

关键词：

myocardial infarction; thrombolysis; fibrinolytics; streptokinase; anistreplase; alteplase; reteplase; tenekteplase;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is reported that the implementation in clinical practice thrombolytic (fibrinolytic) therapy resulted in mortality reduction during first month after myocardial infarction from 17-18% to 5-8%. Different details of this therapy are considered: terms of thrombolysis since the beginning of myocardial infarction, alternative methods of coronary blood flow recovery, indications and contraindications, complications and side effects, estimation of thrombolysis efficacy. Fibrin-selective and fibrin-non-selective drugs are presented. Different fibrinolytics are described: streptokinase, anistreplase, alteplase, reteplase, tenekteplase. The results of large randomized clinical trials devoted to fibrinolytic therapy of myocardial infarction are analyzed: GISSI, ISSIS, TIMI, GUSTO, INJECT, ASSENT. The possibility to increase in efficacy and safety of fibrinolytics by their combination with acetylsalicylic acid, IIb/IIIa receptor inhibitors and heparins are discussed.

引用

页码：58 / 62

页数：5

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