Are the American Society for Radiation Oncology Guidelines Accurate Predictors of Recurrence in Early Stage Breast Cancer Patients Treated with Balloon-Based Brachytherapy?

被引:10
作者
Christoudias, Moira K. [1 ]
Collett, Abigail E. [1 ]
Stull, Tari S. [1 ]
Gracely, Edward J. [2 ]
Frazier, Thomas G. [1 ]
Barrio, Andrea V. [1 ]
机构
[1] Bryn Mawr Hosp, Dept Surg, Bryn Mawr, PA 19010 USA
[2] Drexel Univ, Coll Med, Sch Publ Hlth, Philadelphia, PA 19129 USA
关键词
D O I
10.1155/2013/829050
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The American Society for Radiation Oncology (ASTRO) consensus statement (CS) provides guidelines for patient selection for accelerated partial breast irradiation (APBI) following breast conserving surgery. The purpose of this study was to evaluate recurrence rates based on ASTRO CS groupings. A single institution review of 238 early stage breast cancer patients treated with balloon-based APBI via balloon based brachytherapy demonstrated a 4-year actuarial ipsilateral breast tumor recurrence (IBTR) rate of 5.1%. There were no significant differences in the 4-year actuarial IBTR rates between the "suitable," "cautionary," and "unsuitable" ASTRO categories (0%, 7.2%, and 4.3%, resp.,P = 0.28). ER negative tumors had higher rates of IBTR than ER positive tumors. The ASTRO groupings are poor predictors of patient outcomes. Further studies evaluating individual clinicopathologic features are needed to determine the safety of APBI in higher risk patients.
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页数:7
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共 20 条
  • [1] [Anonymous], 2012, NSABP PROTOCOL B 39
  • [2] Five-year Outcome of Patients Classified in the "Unsuitable" Category Using the American Society of Therapeutic Radiology and Oncology (ASTRO) Consensus Panel Guidelines for the Application of Accelerated Partial Breast Irradiation: An Analysis of Patients Treated on the American Society of Breast Surgeons MammoSite® Registry Trial
    Beitsch, Peter
    Vicini, Frank
    Keisch, Martin
    Haffty, Bruce
    Shaitelman, Simona
    Lyden, Maureen
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2010, 17 : S219 - S225
  • [3] Tumor Bed Control with Balloon-Based Accelerated Partial Breast Irradiation: Incidence of True Recurrences Versus Elsewhere Failures in the American Society of Breast Surgery MammoSite® Registry Trial
    Beitsch, Peter D.
    Ben Wilkinson, J.
    Vicini, Frank A.
    Haffty, Bruce
    Fine, Richard
    Whitworth, Pat
    Kuerer, Henry
    Zannis, Victor
    Lyden, Maureen
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2012, 19 (10) : 3165 - 3170
  • [4] Sequential methotrexate and fluorouracil for the treatment of node-negative breast cancer patients with estrogen receptor-negative tumors: Eight-year results from National Surgical Adjuvant Breast and Bowel Project (NSABP) B-13 and first report of findings from NSABP B-19 comparing methotrexate and fluorouracil with conventional cyclophosphamide, methotrexate, and fluorouracil
    Fisher, B
    Dignam, J
    Mamounas, EP
    Costantino, JP
    Wickerham, DL
    Redmond, C
    Wolmark, N
    Dimitrov, NV
    Bowman, DM
    Glass, AG
    Atkins, JN
    Abramson, N
    Sutherland, CM
    Aron, BS
    Margolese, RG
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1996, 14 (07) : 1982 - 1992
  • [5] A RANDOMIZED CLINICAL-TRIAL EVALUATING TAMOXIFEN IN THE TREATMENT OF PATIENTS WITH NODE-NEGATIVE BREAST-CANCER WHO HAVE ESTROGEN-RECEPTOR POSITIVE TUMORS
    FISHER, B
    COSTANTINO, J
    REDMOND, C
    POISSON, R
    BOWMAN, D
    COUTURE, J
    DIMITROV, NV
    WOLMARK, N
    WICKERHAM, DL
    FISHER, ER
    MARGOLESE, R
    ROBIDOUX, A
    SHIBATA, H
    TERZ, J
    PATERSON, AHG
    FELDMAN, MI
    FARRAR, W
    EVANS, J
    LICKLEY, HL
    KETNER, M
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (08) : 479 - 484
  • [6] LONG-TERM OUTCOME FOLLOWING BREAST-CONSERVING SURGERY AND RADIATION-THERAPY
    GAGE, I
    RECHT, A
    GELMAN, R
    NIXON, AJ
    SILVER, B
    BORNSTEIN, BA
    HARRIS, JR
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1995, 33 (02): : 245 - 251
  • [7] Hammond EH, 2010, CANC J CLIN ONCOL, V28, P2784
  • [8] HOLLAND R, 1985, CANCER, V56, P979, DOI 10.1002/1097-0142(19850901)56:5<979::AID-CNCR2820560502>3.0.CO
  • [9] 2-N
  • [10] The biologic rationale for and emerging role of accelerated partial breast irradiation for breast cancer
    Pawlik, TM
    Buchholz, TA
    Kuerer, HM
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2004, 199 (03) : 479 - 492