ANALYSIS OF DIASTEREOISOMER IMPURITIES IN CHIRAL PHARMACEUTICAL COMPOUNDS BY CAPILLARY ELECTROPHORESIS

被引：14

作者：

WILLIAMS, RC

EDWARDS, JF

AINSWORTH, CR

机构：

[1] Pharmaceutical Research and Development, The DuPont Merck Pharmaceutical Company, Wilmington, 19880-0353, DE

来源：

CHROMATOGRAPHIA | 1994年 / 38卷 / 7-8期

关键词：

CAPILLARY ELECTROPHORESIS; MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY; DIASTEREOISOMERS; CHIRAL IMPURITIES; PHARMACEUTICAL COMPOUNDS;

D O I：

10.1007/BF02269833

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Micellar electrokinetic capillary chromatography (MECC) has been applied to the separation and analysis of diastereoisomer impurities in chiral pharmaceutical compounds. Differences in separation mechanism and selectivity make MECC useful as an alternative method to HPLC for analysis of these synthetic impurities. Advantages of MECC include high efficiency separations and low consumption of sample and solvents. Water soluble and insoluble pharmaceutical compounds are used to illustrate the separation characteristics and quantitative capabilities of this versatile new analytical technique.

引用

页码：441 / 446

页数：6

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