REGULATION OF INTERLEUKIN-6 RECEPTOR EXPRESSION BY INTERLEUKIN-6 IN HUMAN MONOCYTES - A REEXAMINATION

被引：15

作者：

SCHOESTER, M ^{[1
]}

HEINRICH, PC ^{[1
]}

GRAEVE, L ^{[1
]}

机构：

[1] RHEIN WESTFAL TH AACHEN HOSP,INST BIOCHEM,D-52057 AACHEN,GERMANY

来源：

FEBS LETTERS | 1994年 / 345卷 / 2-3期

关键词：

INTERLEUKIN-6; CYTOKINE RECEPTOR; LIPOPOLYSACCHARIDE; MONOCYTE;

D O I：

10.1016/0014-5793(94)00416-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have studied the expression and regulation of the interleukin-6 receptor (gp80) and its signal transducer gp130 in primary human blood monocytes. Here, we show that freshly isolated human monocytes express mRNAs for gp80 and gp130. In contrast to a previous report [(1989) FEBS Lett. 249, 27-30] we find that neither lipopolysaccharide nor interleukin-6 (IL-6) lead to a down-regulation of IL-6 receptor mRNA in monocytes. Also in the human monocytic cell line Mono Mac 6 no effect of IL-6 on receptor mRNA levels was observed. For signal transducer gp130 mRNA in monocytes a small and transient up-regulation by IL-6 was found.

引用

页码：131 / 134

页数：4

共 32 条

[11] MOLECULAR-CLONING AND EXPRESSION OF AN IL-6 SIGNAL TRANSDUCER, GP130 [J].

HIBI, M ;

MURAKAMI, M ;

SAITO, M ;

HIRANO, T ;

TAGA, T ;

KISHIMOTO, T .

CELL, 1990, 63 (06) :1149-1157

[12] THE BIOLOGY OF INTERLEUKIN-6 [J].

KISHIMOTO, T .

BLOOD, 1989, 74 (01) :1-10

[13]

NESBITT JE, 1992, J BIOL CHEM, V267, P5739

[14] THE INFLAMMATION MEDIATORS INTERLEUKIN-1 AND HEPATOCYTE-STIMULATING FACTOR ARE DIFFERENTLY REGULATED IN HUMAN-MONOCYTES [J].

NORTHOFF, H ;

ANDUS, T ;

TRANTHI, TA ;

BAUER, J ;

DECKER, K ;

KUBANEK, B ;

HEINRICH, PC .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1987, 17 (05) :707-711

[15] A NOVEL NEUTROPHIL-ACTIVATING FACTOR PRODUCED BY HUMAN MONONUCLEAR PHAGOCYTES [J].

PEVERI, P ;

WALZ, A ;

DEWALD, B ;

BAGGIOLINI, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (05) :1547-1559

[16]

PIETZKO D, 1993, J BIOL CHEM, V268, P4250

[17]

PORTIER M, 1993, BLOOD, V81, P3076

[18] UP-REGULATION OF INTERLEUKIN (IL)-6 RECEPTOR GENE-EXPRESSION INVITRO AND INVIVO IN IL-6 DEPRIVED MYELOMA CELLS [J].

PORTIER, M ;

LEES, D ;

CARON, E ;

JOURDAN, M ;

BOIRON, JM ;

BATAILLE, R ;

KLEIN, B .

FEBS LETTERS, 1992, 302 (01) :35-38

[19]

Roberts A. B., 1990, PEPTIDE GROWTH FACTO, P633

[20] STUDIES ON THE STRUCTURE AND REGULATION OF THE HUMAN HEPATIC INTERLEUKIN-6 RECEPTOR [J].

ROSEJOHN, S ;

SCHOOLTINK, H ;

LENZ, D ;

HIPP, E ;

DUFHUES, G ;

SCHMITZ, H ;

SCHIEL, X ;

HIRANO, T ;

KISHIMOTO, T ;

HEINRICH, PC .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 190 (01) :79-83

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