REGULATION OF INTERLEUKIN-6 RECEPTOR EXPRESSION BY INTERLEUKIN-6 IN HUMAN MONOCYTES - A REEXAMINATION

被引：15
作者：
SCHOESTER, M [1 ]
HEINRICH, PC [1 ]
GRAEVE, L [1 ]
机构：
[1] RHEIN WESTFAL TH AACHEN HOSP,INST BIOCHEM,D-52057 AACHEN,GERMANY
来源：
FEBS LETTERS | 1994年 / 345卷 / 2-3期
关键词：
INTERLEUKIN-6; CYTOKINE RECEPTOR; LIPOPOLYSACCHARIDE; MONOCYTE;
D O I：
10.1016/0014-5793(94)00416-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have studied the expression and regulation of the interleukin-6 receptor (gp80) and its signal transducer gp130 in primary human blood monocytes. Here, we show that freshly isolated human monocytes express mRNAs for gp80 and gp130. In contrast to a previous report [(1989) FEBS Lett. 249, 27-30] we find that neither lipopolysaccharide nor interleukin-6 (IL-6) lead to a down-regulation of IL-6 receptor mRNA in monocytes. Also in the human monocytic cell line Mono Mac 6 no effect of IL-6 on receptor mRNA levels was observed. For signal transducer gp130 mRNA in monocytes a small and transient up-regulation by IL-6 was found.
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页码：131 / 134
页数：4
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