REGULATION OF INTERLEUKIN-6 RECEPTOR EXPRESSION BY INTERLEUKIN-6 IN HUMAN MONOCYTES - A REEXAMINATION

被引：15
|
作者：
SCHOESTER, M [1 ]
HEINRICH, PC [1 ]
GRAEVE, L [1 ]
机构：
[1] RHEIN WESTFAL TH AACHEN HOSP,INST BIOCHEM,D-52057 AACHEN,GERMANY
来源：
FEBS LETTERS | 1994年 / 345卷 / 2-3期
关键词：
INTERLEUKIN-6; CYTOKINE RECEPTOR; LIPOPOLYSACCHARIDE; MONOCYTE;
D O I：
10.1016/0014-5793(94)00416-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have studied the expression and regulation of the interleukin-6 receptor (gp80) and its signal transducer gp130 in primary human blood monocytes. Here, we show that freshly isolated human monocytes express mRNAs for gp80 and gp130. In contrast to a previous report [(1989) FEBS Lett. 249, 27-30] we find that neither lipopolysaccharide nor interleukin-6 (IL-6) lead to a down-regulation of IL-6 receptor mRNA in monocytes. Also in the human monocytic cell line Mono Mac 6 no effect of IL-6 on receptor mRNA levels was observed. For signal transducer gp130 mRNA in monocytes a small and transient up-regulation by IL-6 was found.
引用
收藏
页码：131 / 134
页数：4
相关论文
共 50 条
  • [1] Expression of interleukin-6 and interleukin-6 receptors in human granulosa lutein cells
    Keck, C
    Rajabi, Z
    Pfeifer, K
    Bettendorf, H
    Brandstetter, T
    Breckwoldt, M
    MOLECULAR HUMAN REPRODUCTION, 1998, 4 (11) : 1071 - 1076
  • [2] Interleukin-6 expression and regulation in astrocytes
    Van Wagoner, NJ
    Benveniste, EN
    JOURNAL OF NEUROIMMUNOLOGY, 1999, 100 (1-2) : 124 - 139
  • [3] INTERLEUKIN-6 AND INTERLEUKIN-6 RECEPTOR GENE-EXPRESSION IN PITUITARY-TUMORS
    REZAI, AR
    REZAI, A
    MARTINEZMAZA, O
    VANDERMEYDEN, M
    WEISS, MH
    JOURNAL OF NEURO-ONCOLOGY, 1994, 19 (02) : 131 - 135
  • [4] The clinical role of interleukin-6 and interleukin-6 soluble receptor in human follicular fluids
    Kawasaki, F
    Kawano, Y
    Hasan, ZK
    Narahara, H
    Miyakawa, I
    CLINICAL AND EXPERIMENTAL MEDICINE, 2003, 3 (01) : 27 - 31
  • [5] Fusion protein of interleukin-6 and interleukin-6 receptor without a polypeptide linker
    Yasukawa, K
    Tsuchiya, S
    Ekida, T
    Iida, H
    Ide, T
    Miki, D
    Yagame, H
    Murayama, K
    Ishiguroi, T
    JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2003, 96 (01) : 38 - 46
  • [6] Serum interleukin-6 soluble receptor in relation to interleukin-6 in stroke patients
    Tomasz Dziedzic
    Elzbieta A. Gryz
    Wojciech Turaj
    Agnieszka Slowik
    Andrzej Szczudlik
    Journal of Molecular Neuroscience, 2004, 24 : 293 - 298
  • [7] Expression of Interleukin-6 and the Interleukin-6 Receptor Predicts the Clinical Outcomes of Patients with Soft Tissue Sarcomas
    Nakamura, Koichi
    Nakamura, Tomoki
    Iino, Takahiro
    Hagi, Tomohito
    Kita, Kouji
    Asanuma, Kunihiro
    Sudo, Akihiro
    CANCERS, 2020, 12 (03)
  • [8] Serum interleukin-6 and interleukin-6 soluble receptor in Alzheimer's disease
    Angelis, P
    Scharf, S
    Mander, A
    Vajda, F
    Christophidis, N
    NEUROSCIENCE LETTERS, 1998, 244 (02) : 106 - 108
  • [9] The interleukin-6 regulates the function of monocytes/macrophages (MO/MΦ) via the interleukin-6 receptor β in ayu (Plecoglossus altivelis)
    Zhu, Kai
    Lu, Xin-Jiang
    Lu, Jian-Fei
    Chen, Jiong
    FISH & SHELLFISH IMMUNOLOGY, 2019, 93 : 191 - 199
  • [10] Serum interleukin-6 soluble receptor in relation to interleukin-6 in stroke patients
    Dziedzic, T
    Gryz, EA
    Turaj, W
    Slowik, A
    Szczudlik, A
    JOURNAL OF MOLECULAR NEUROSCIENCE, 2004, 24 (02) : 293 - 298
12345