COMPARISON OF ANTIMALARIAL EFFICACY OF ALPHA-ARTEETHER, BETA-ARTEETHER AND ALPHA-BETA-ARTEETHER AGAINST PLASMODIUM-CYNOMOLGI-B INFECTION IN MONKEYS

被引：12

作者：

TRIPATHI, R ^{[1
]}

DUTTA, GP ^{[1
]}

VISHWAKARMA, RA ^{[1
]}

机构：

[1] INST MED & AROMAT PLANTS,LUCKNOW,INDIA

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 1991年 / 44卷 / 05期

关键词：

D O I：

10.4269/ajtmh.1991.44.560

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The blood schizontocidal activity of alpha and beta-arteether has been compared with that of apha/beta arteether (a 30:70 mixture of alpha and beta-isomers), which is a fast-acting blood schizontocide undergoing phase I clinical trials at the Central Drug Research Institute. Both beta and alpha/beta-arteether have comparable activity and are curative at a dose of 5 mg/kg for 3 days against blood-induced Plasmodium cynomolgi B infection in the rhesus monkey; alpha-arteether alone is slightly less active, with a 50% cure rate at the above dose.

引用

页码：560 / 563

页数：4

共 13 条

[1]

[Anonymous], 1982, J TRADIT CHIN MED, V2, P45

[2] BLOOD SCHIZONTOCIDAL ACTIVITY OF A NEW ANTIMALARIAL DRUG, ARTEETHER (ALPHA-BETA), AGAINST PLASMODIUM-KNOWLESI IN RHESUS-MONKEYS [J].