BLOCKADE OF NITRIC-OXIDE SYNTHASE INHIBITS NERVE-MEDIATED CONTRACTION IN THE RAT SMALL-INTESTINE

被引：35

作者：

BARTHO, L ^{[1
]}

KOCZAN, G ^{[1
]}

PETHO, G ^{[1
]}

MAGGI, CA ^{[1
]}

机构：

[1] A MENARINI PHARMACEUT,DEPT PHARMACOL,FLORENCE,ITALY

来源：

NEUROSCIENCE LETTERS | 1992年 / 145卷 / 01期

关键词：

ENTERIC NEURON; NITRIC OXIDE; SMOOTH MUSCLE CONTRACTION; RAT ILEUM;

D O I：

10.1016/0304-3940(92)90199-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Inhibitors of nitric oxide (NO) synthase inhibit nerve-mediated non-adrenergic, non-cholinergic (NANC) smooth muscle relaxation in the gastrointestinal tract. In this study, the effect of a NO synthase inhibitor, N(G)-nitro-L-arginine, was examined on the tetrodotoxin-sensitive NANC contractile response of the rat isolated ileal myenteric plexus-longitudinal muscle evoked by electrical field stimulation. This contraction was concentration-dependently inhibited by N(G)-nitro-L-arginine (1-3 x 10(-5) M). The inhibition was partly or entirely reversed by L-arginine. The NO synthase inhibitor did not exhibit any non-specific smooth-muscle depressant action or local anaesthetic effect. Sodium nitroprusside, a putative donor of NO also caused a transient contraction of the rat ileal strip. This response was resistant to tetrodotoxin. It is concluded that an NO synthase product is involved in the mechanism of the nerve-mediated NANC primary contraction due to field stimulation in the rat small intestine.

引用

页码：43 / 46

页数：4

共 15 条

[1]

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