STRUCTURAL FACTORS AFFECTING CHIRAL RECOGNITION AND SEPARATION ON CELLULOSE BASED CHIRAL STATIONARY PHASES

被引：28

作者：

ABOULENEIN, HY

ISLAM, MR

机构：

[1] Drug Development Laboratory, Radionuclide & Cyclotron Operations Department, King Faisal Specialist Hospital & Research Centre, Riyadh

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1990年 / 13卷 / 03期

关键词：

D O I：

10.1080/01483919008051800

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The structural factors and functional group selectivity requirements affecting direct high-performance liquid chromatographic enantiomeric resolution of drug racemates on several derivatized cellulose chiral stationary phases are reviewed. A. guide for the choice of the appropriate chiral cellulose derivative column based on elements of asymmetry and functional groups of the compounds are presented. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：485 / 492

页数：8

共 20 条

[1] CHROMATOGRAPHIC RESOLUTION OF CHIRAL DRUGS ON POLYAMIDES AND CELLULOSE TRIACETATE [J].

BLASCHKE, G .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1986, 9 (2-3) :341-368

[2]

Blaschke G., 1980, ANGEW CHEM, V92, P14

[3] APPLICATIONS AND LIMITATIONS OF COMMERCIALLY AVAILABLE CHIRAL STATIONARY PHASES FOR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

DAPPEN, R ;

ARM, H ;

MEYER, VR .

JOURNAL OF CHROMATOGRAPHY, 1986, 373 (01) :1-20

[4] PHARMACODYNAMIC AND PHARMACOKINETIC DIFFERENCES BETWEEN DRUG ENANTIOMERS IN HUMANS - AN OVERVIEW [J].

DRAYER, DE .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1986, 40 (02) :125-133

[5]

ELIEL EL, 1962, STEREOCHEMISTRY CARB, P33

[6] CHIRAL PHARMACOLOGY AND ITS CONSEQUENCES FOR THERAPEUTIC MONITORING [J].

HUBBARD, JW ;

GANES, D ;

LIM, HK ;

MIDHA, KK .

CLINICAL BIOCHEMISTRY, 1986, 19 (02) :107-112

[7]

KRUSTULOVIC AM, 1987, J CHROMATOGR, V411, P461

[8] STEREOISOMERISM AND DRUG-ACTION [J].

LEHMANN, PA .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1986, 7 (07) :281-285

[9]

MASON S, 1984, NEW SCI, V10, P1393

[10] CHROMATOGRAPHIC RESOLUTION .12. OPTICAL RESOLUTION OF BETA-BLOCKERS BY HPLC ON CELLULOSE TRIPHENYLCARBAMATE DERIVATIVES [J].

OKAMOTO, Y ;

KAWASHIMA, M ;

ABURATANI, R ;

HATADA, K ;

NISHIYAMA, T ;

MASUDA, M .

CHEMISTRY LETTERS, 1986, (07) :1237-1240

← 1 2 →