QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP OF ANTIFOLATE INHIBITION OF BACTERIA CELL-CULTURES RESISTANT AND SENSITIVE TO METHOTREXATE

被引:18
作者
COATS, EA
GENTHER, CS
SELASSIE, CD
STRONG, CD
HANSCH, C
机构
[1] UNIV CINCINNATI,MED CTR,COLL PHARM,CINCINNATI,OH 45267
[2] POMONA COLL,DEPT CHEM,CLAREMONT,CA 91711
关键词
D O I
10.1021/jm00150a026
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1910 / 1916
页数:7
相关论文
共 19 条
[1]   STRUCTURE ACTIVITY RELATIONSHIPS OF DIHYDROFOLATE-REDUCTASE INHIBITORS [J].
BLANEY, JM ;
HANSCH, C ;
SILIPO, C ;
VITTORIA, A .
CHEMICAL REVIEWS, 1984, 84 (04) :333-407
[2]  
BOLIN JT, 1982, J BIOL CHEM, V257, P13650
[3]   COMPARISON OF THE INHIBITION OF METHOTREXATE-SENSITIVE AND METHOTREXATE-RESISTANT LACTOBACILLUS-CASEI CELL-CULTURES WITH PURIFIED LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE BY 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-(3-SUBSTITUTED-PHENYL)-S-TRIAZINES - USE OF QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS IN MAKING INFERENCES ABOUT THE MECHANISM OF RESISTANCE AND THE STRUCTURE OF THE ENZYME INSITU COMPARED WITH THE ENZYME INVITROUA [J].
COATS, EA ;
GENTHER, CS ;
DIETRICH, SW ;
GUO, Z ;
HANSCH, C .
JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (12) :1422-1429
[4]   QUANTITATIVE STRUCTURE-SELECTIVITY RELATIONSHIPS - COMPARISON OF THE INHIBITION OF ESCHERICHIA-COLI AND BOVINE LIVER DIHYDROFOLATE-REDUCTASE BY 5-(SUBSTITUTED-BENZYL)-2,4-DIAMINOPYRIMIDINES [J].
DIETRICH, SW ;
BLANEY, JM ;
REYNOLDS, MA ;
JOW, PYC ;
HANSCH, C .
JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (11) :1205-1212
[5]   USE OF TRIAZINE INHIBITORS IN MAPPING THE ACTIVE-SITE REGION OF LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE [J].
DIETRICH, SW ;
SMITH, RN ;
BRENDLER, S ;
HANSCH, C .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1979, 194 (02) :612-619
[6]   RHO-SIGMA-PI ANALYSIS . METHOD FOR CORRELATION OF BIOLOGICAL ACTIVITY + CHEMICAL STRUCTURE [J].
HANSCH, C ;
FUJITA, T .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (08) :1616-&
[7]   CRYSTALLOGRAPHY, QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS, AND MOLECULAR GRAPHICS IN A COMPARATIVE-ANALYSIS OF THE INHIBITION OF DIHYDROFOLATE-REDUCTASE FROM CHICKEN LIVER AND LACTOBACILLUS-CASEI BY 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-(SUBSTITUTED-PHENYL)-S-TRIAZINESAN [J].
HANSCH, C ;
HATHAWAY, BA ;
GUO, ZR ;
SELASSIE, CD ;
DIETRICH, SW ;
BLANEY, JM ;
LANGRIDGE, R ;
VOLZ, KW ;
KAUFMAN, BT .
JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (02) :129-143
[8]  
Hansch C, 1979, SUBSTITUENT CONSTANT
[9]   QUANTITATIVE STRUCTURE-SELECTIVITY RELATIONSHIPS - COMPARISON OF THE INHIBITION OF ESCHERICHIA-COLI AND BOVINE LIVER DIHYDROFOLATE-REDUCTASE BY 5-(SUBSTITUTED-BENZYL)-2,4-DIAMINOPYRIMIDINES [J].
LI, RL ;
DIETRICH, SW ;
HANSCH, C .
JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (05) :538-544
[10]   A COMPARISON OF THE INHIBITORY-ACTION OF 5-(SUBSTITUTED-BENZYL)-2,4-DIAMINOPYRIMIDINES ON DIHYDROFOLATE-REDUCTASE FROM CHICKEN LIVER WITH THAT FROM BOVINE LIVER [J].
LI, RL ;
HANSCH, C ;
KAUFMAN, BT .
JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (04) :435-440