STUDY ON AMOXICILLIN WITH THE COMPARISON OF CLAVULANATE: A LIVER INJURY CASE CONTROL STUDY

Introduction: The liver injury is reported often as secondary to hypersensitivity drug allergy resulting in centrizonal cholestasis, progressing to hepatocellular damage. In severe reactions, bile duct injury has been reported. Objectives of the study: The main objective of the study is to find the role of Amoxicillin with the comparison of Clavulanate for drug induced liver injury in hepatic patients. Methodology of the study: This study was conducted at the Islamic international medical college (RIU Islamabad) and Department of Pharmacy & alternative medicine, The Islamia University of Bahawalpur during 2018 with the permission of ethical committee of hospital. For this purpose we select the 30 patients who was suffering from chronic hepatic injury due to the excessive use of drugs especially Amoxicillin and Clavulanate. Results: We analyzed 30 cases matched to controls. Seven cases were exposed to amoxicillin (adjusted OR 1.69, 95% CI 0.72-3.98) and 13 cases to co-amoxiclav (adjusted OR 3.00, 95% CI 1.76-5.40). Conclusion: It is concluded that compared to amoxicillin alone, amoxicillin + clavulanic acid doubles the risk of serious acute liver injury, in agreement with most studies on DILI.