Sustained complete remission of steroid- and cyclophosphamide-resistant minimal-change disease with a single course of rituximab therapy

被引：5

作者：

Janardan, Jyotsna ^{[1
]}

Ooi, Khai ^{[1
]}

Menahem, Solomon ^{[1
]}

机构：

[1] Alfred Hosp, Dept Renal Med, Melbourne, Vic, Australia

来源：

CLINICAL KIDNEY JOURNAL | 2014年 / 7卷 / 03期

关键词：

minimal-change disease; nephrotic syndrome; rituximab; steroid resistance;

D O I：

10.1093/ckj/sfu022

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of steroid- and cyclophosphamide-resistant nephrotic syndrome secondary to minimal-change disease occurring in an otherwise healthy 19-year-old female, responding rapidly to two doses of rituximab therapy. Complete disease remission has been sustained up to last follow-up (32 months) despite CD19 recovery. Literature review suggests emerging evidence that rituximab may have a role to play in recurrent and/or refractory minimal-change disease.

引用

页码：293 / 295

页数：3

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