REGIOSELECTIVE PROTECTION OF THE 2'-HYDROXYL GROUP OF N-ACYL-3',5'-O-DI(T-BUTYL)SILANEDIYLNUCLEOSIDE DERIVATIVES BY USE OF T-BUMGCL AND 2-(TRIMETHYLSILYL)ETHOXYMETHYL CHLORIDE

被引：23

作者：

WADA, T

TOBE, M

NAGAYAMA, T

FURUSAWA, K

SEKINE, M

机构：

[1] TOKYO INST TECHNOL,FAC BIOSCI & BIOTECHNOL,DEPT LIFE SCI,MIDORI KU,YOKOHAMA,KANAGAWA 227,JAPAN

[2] RES INST POLYMERS & TEXT,IBARAKI,OSAKA 305,JAPAN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 10期

关键词：

D O I：

10.1016/0040-4039(95)00130-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Regioselective 2'-O-protection of N-protected 3',5'-O-di(t-butyl)silanediylribonucleoside derivatives with the 2-(trimethylsilyl)ethoxymethyl (SEM) group has been achieved by use of t-BuMgCl and 2-(trimethylsilyl)ethoxymethyl chloride. The former was used as a base. The 2'-O-SEM protected ribonucleoside derivatives were converted via a three-step reaction into the corresponding phosphoramidite building blocks in good overall yields.

引用

页码：1683 / 1684

页数：2

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