IMPACT OF OMEPRAZOLE ON THE PLASMA-CLEARANCE OF METHOTREXATE

被引：48

作者：

REID, T

YUEN, A

CATOLICO, M

CARLSON, RW

机构：

[1] STANFORD UNIV,MED CTR,DEPT MED,DIV MED ONCOL,STANFORD,CA 94305

[2] STANFORD UNIV HOSP,DEPT PHARM,STANFORD,CA 94305

来源：

CANCER CHEMOTHERAPY AND PHARMACOLOGY | 1993年 / 33卷 / 01期

关键词：

OMEPRAZOLE; METHOTREXATE; PHARMACOKINETICS; KIDNEY;

D O I：

10.1007/BF00686028

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Omeprazole inhibits the gastric hydrogen pump and is an effective treatment for peptic ulcers. Methotrexate is a chemotherapeutic agent that inhibits dihydrofolate reductase and is eliminated by a hydrogen-ion-dependent mechanism in the kidney. We present evidence that omeprazole inhibits methotrexate clearance and may result in potentially toxic methotrexate levels.

引用

页码：82 / 84

页数：3

共 27 条

[1] METHOTREXATE-INDUCED RENAL IMPAIRMENT - CLINICAL-STUDIES AND RESCUE FROM SYSTEMIC TOXICITY WITH HIGH-DOSE LEUCOVORIN AND THYMIDINE [J].