FUTURE-RESEARCH DIRECTIONS IN CANCER ECOGENETICS

被引：35
作者：
OMENN, GS
机构：
[1] School of Public Health and Community, Medicine, University of Washington SC-30, Seattle
来源：
MUTATION RESEARCH | 1991年 / 247卷 / 02期
关键词：
CANCER ECOGENETICS; ECOGENETICS; CANCER; POLYMORPHISMS; RISK CHARACTERIZATION; BIOTRANSFORMATION;
D O I：
10.1016/0027-5107(91)90023-H
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
There are many productive directions for future research in cancer ecogenetics. Genetic variation in susceptibility to chemicals and other carcinogenic agents has been neglected in most epidemiologic and rodent investigations of cancer etiology. Genetic variation isimportant to characterization of risks for population subgroups. Genetic investigations also may enhance inquiries into the underlying mechanisms of carcinogenesis and of cancer prevention. Polymorphisms of cytochrome P450 mono-oxygenases, epoxide hydrolase, glutathione-S-transferases, and N-acetyltransferase offer important windows on biotransformation of pro-carcinogens. Assays in peripheral blood cells need to be related closely to variation in activity in target organs. Tumor suppressor genes, signal transduction pathways, and cell surface receptors are additional sites where genetic variation would be highly important to cancer risks.
引用
收藏
页码：283 / 291
页数：9
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