THE USE OF MIDAZOLAM VERSUS PROPOFOL FOR SHORT-TERM SEDATION FOLLOWING CORONARY-ARTERY BYPASS-GRAFTING

Midazolam and propofol were compared in an open randomized study for postoperative sedation during 12 h of mechanical ventilation in 40 patients following coronary artery bypass grafting. After an intravenous loading dose of midazolam (50 μg · kg-1) or propofol (500 μg · kg-1), a titrated continuous infusion was administered of midazolam (mean dose 38.1 μg · kg-1 · h-1 (SEM 2.6)) or propofol (mean dose 909 μg · kg-1 · h-1 (SEM 100)) together with a narcotic analgesic infusion. During mechanical ventilation midazolam and propofol produced a similar quality of sedation, but recovery (midazolam 66 min (SEM 16); propofol 24 min (SEM 7)) and weaning from the ventilator (midazolam 243 min (SEM 44); propofol 154 min (SEM 33)) where faster with propofol. In the 2 groups administration of an intravenous loading dose caused a significant decrease in mean arterial pressure but hemodynamic tolerance during maintenance infusion was good. © 1990 Springer-Verlag.