A New Candidate Supporting Drug, Rikkunshito, for the QOL in Advanced Esophageal Cancer Patients with Chemotherapy Using Docetaxel/5-FU/CDDP

被引：22

作者：

Seike, Junichi ^{[1
]}

Sawada, Toru ^{[1
]}

Kawakita, Naoya ^{[1
]}

Yamamoto, Yota ^{[1
]}

Yuasa, Yasuhiro ^{[1
]}

Yamai, Hiromichi ^{[1
]}

Takachi, Hirokazu ^{[1
]}

Yoshida, Takahiro ^{[1
]}

Tangoku, Akira ^{[1
]}

机构：

[1] Univ Tokushima, Inst Hlth Biosci, Dept Thorac Endocrine Surg & Oncol, Grad Sch, Tokushima 7708503, Japan

来源：

INTERNATIONAL JOURNAL OF SURGICAL ONCOLOGY | 2011年 / 2011卷

关键词：

D O I：

10.1155/2011/715623

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose. Docetaxel/5-FU/CDDP (DFP) therapy is a useful treatment for advanced esophageal cancer. However, adverse reactions such as chemotherapy-induced nausea and vomiting (CINV) interfere often with continuation of the chemotherapy. We investigated the efficacy of rikkunshito (TJ-43) on CINV. Methods. Nineteen patients who were going to undergo DFP therapy were enrolled. They were assigned to the following two groups: a TJ-43-treated group and -nontreated group. The following parameters were compared between the 2 groups: (1) the frequency of symptoms occurred, (2) vomiting, nausea, and anorexia score, and (3) QOL score. Results. The incidence of symptoms was lower in the TJ-43-treated group than that in the control group. The nausea score of the TJ-43-treated group was significantly lower than that of the control group. In the QOL score, the mood score and the ADL score decreased significantly in the control group. Conclusion. We recommend TJ-43 administration in patients undergoing DFP chemotherapy.

引用

页数：7

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