SMALL, DENSE LOW-DENSITY-LIPOPROTEIN AS A RISK FACTOR FOR CORONARY HEART-DISEASE

被引:44
作者
AUSTIN, MA
机构
[1] Department of Epidemiology, School of Public Health and Community Medicine, SC-36
[2] University of Washington, Seattle, 98195, WA
关键词
SMALL; DENSE LOW-DENSITY LIPOPROTEIN; CORONARY HEART DISEASE; RISK FACTOR;
D O I
10.1007/BF02592460
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Data from case-control and cross-sectional studies uniformly demonstrate an association between small, dense low-density lipoprotein and risk of coronary heart disease. This relationship may be attributable to the association of small, dense low-density lipoprotein with other atherogenic lipoproteins, the presence of the insulin resistance syndrome in subjects with small low-density lipoprotein, and/or the increased oxidative susceptibility of small, dense low-density lipoprotein particles. Furthermore, because small low-density lipoprotein appears to be a common trait in the general population, more than one of these atherogenic mechanisms may be operating simultaneously to increase risk of coronary heart disease.
引用
收藏
页码:187 / 192
页数:6
相关论文
共 41 条
[1]   INHERITANCE OF LOW-DENSITY-LIPOPROTEIN SUBCLASS PATTERNS IN FAMILIAL COMBINED HYPERLIPIDEMIA [J].
AUSTIN, MA ;
BRUNZELL, JD ;
FITCH, WL ;
KRAUSS, RM .
ARTERIOSCLEROSIS, 1990, 10 (04) :520-530
[2]  
AUSTIN MA, 1988, JAMA-J AM MED ASSOC, V260, P1917
[3]   ATHEROGENIC LIPOPROTEIN PHENOTYPE - A PROPOSED GENETIC-MARKER FOR CORONARY HEART-DISEASE RISK [J].
AUSTIN, MA ;
KING, MC ;
VRANIZAN, KM ;
KRAUSS, RM .
CIRCULATION, 1990, 82 (02) :495-506
[4]   INFLUENCE OF OBESITY, IMPAIRED GLUCOSE-TOLERANCE, AND NIDDM ON LDL STRUCTURE AND COMPOSITION - POSSIBLE LINK BETWEEN HYPERINSULINEMIA AND ATHEROSCLEROSIS [J].
BARAKAT, HA ;
CARPENTER, JW ;
MCLENDON, VD ;
KHAZANIE, P ;
LEGGETT, N ;
HEATH, J ;
MARKS, R .
DIABETES, 1990, 39 (12) :1527-1533
[5]   LOW-DENSITY-LIPOPROTEIN PARTICLE-SIZE AND CORONARY-ARTERY DISEASE [J].
CAMPOS, H ;
GENEST, JJ ;
BLIJLEVENS, E ;
MCNAMARA, JR ;
JENNER, JL ;
ORDOVAS, JM ;
WILSON, PWF ;
SCHAEFER, EJ .
ARTERIOSCLEROSIS AND THROMBOSIS, 1992, 12 (02) :187-195
[6]   SUSCEPTIBILITY OF SMALL, DENSE, LOW-DENSITY LIPOPROTEINS TO OXIDATIVE MODIFICATION IN SUBJECTS WITH THE ATHEROGENIC LIPOPROTEIN PHENOTYPE, PATTERN-B [J].
CHAIT, A ;
BRAZG, RL ;
TRIBBLE, DL ;
KRAUSS, RM .
AMERICAN JOURNAL OF MEDICINE, 1993, 94 (04) :350-356
[7]  
CHEUNG MC, 1991, J LIPID RES, V32, P383
[8]  
CORESH J, 1993, J LIPID RES, V34, P1687
[9]  
CROUSE JR, 1985, J LIPID RES, V26, P566
[10]   INSULIN RESISTANCE - A MULTIFACETED SYNDROME RESPONSIBLE FOR NIDDM, OBESITY, HYPERTENSION, DYSLIPIDEMIA, AND ATHEROSCLEROTIC CARDIOVASCULAR-DISEASE [J].
DEFRONZO, RA ;
FERRANNINI, E .
DIABETES CARE, 1991, 14 (03) :173-194