3-DIMENSIONAL ARCHITECTURE OF THE SKELETAL-MUSCLE RYANODINE RECEPTOR

被引：43
作者：
WAGENKNECHT, T [1 ]
RADERMACHER, M [1 ]
机构：
[1] SUNY ALBANY,SCH PUBL HLTH,DEPT BIOMED SCI,ALBANY,NY
来源：
FEBS LETTERS | 1995年 / 369卷 / 01期
关键词：
RYANODINE RECEPTOR; CALCIUM RELEASE; CRYOELECTRON MICROSCOPY; 3-DIMENSIONAL RECONSTRUCTION; EXCITATION-CONTRACTION; MUSCLE; IMAGE PROCESSING;
D O I：
10.1016/0014-5793(95)00581-S
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent advances in determining the three-dimensional architecture of the skeletal muscle ryanodine receptor/calcium release channel (RyR) by cryo-electron microscopy and three-dimensional reconstruction are discussed, The tetrameric receptor is characterized by a large 4-fold symmetric cytoplasmic assembly that consists of many domains separated by solvent-containing crevices and holes, Experimental evidence suggests that at least one regulatory ligand, calmodulin, binds to sites on the cytoplasmic assembly that are at least 10 nanometers from the transmembrane channel.
引用
收藏
页码：43 / 46
页数：4
相关论文
共 33 条
[21]  
Serysheva Irina I., 1995, Biophysical Journal, V68, pA128
[22]   CALMODULIN MODULATION OF SINGLE SARCOPLASMIC-RETICULUM CA-2+-RELEASE CHANNELS FROM CARDIAC AND SKELETAL-MUSCLE [J].
SMITH, JS ;
ROUSSEAU, E ;
MEISSNER, G .
CIRCULATION RESEARCH, 1989, 64 (02) :352-359
[23]   RESTORATION OF JUNCTIONAL TETRADS IN DYSGENIC MYOTUBES BY DIHYDROPYRIDINE RECEPTOR CDNA [J].
TAKEKURA, H ;
BENNETT, L ;
TANABE, T ;
BEAN, KG ;
FRANZINIARMSTRONG, C .
BIOPHYSICAL JOURNAL, 1994, 67 (02) :793-803
[24]   PRIMARY STRUCTURE AND EXPRESSION FROM COMPLEMENTARY-DNA OF SKELETAL-MUSCLE RYANODINE RECEPTOR [J].
TAKESHIMA, H ;
NISHIMURA, S ;
MATSUMOTO, T ;
ISHIDA, H ;
KANGAWA, K ;
MINAMINO, N ;
MATSUO, H ;
UEDA, M ;
HANAOKA, M ;
HIROSE, T ;
NUMA, S .
NATURE, 1989, 339 (6224) :439-445
[25]   CHARACTERIZATION OF AN EXCHANGE-REACTION BETWEEN SOLUBLE FKBP-12 AND THE FKBP RYANODINE RECEPTOR COMPLEX - MODULATION BY FKBP MUTANTS DEFICIENT IN PEPTIDYL-PROLYL ISOMERASE ACTIVITY [J].
TIMERMAN, AP ;
WIEDERRECHT, G ;
MARCY, A ;
FLEISCHER, S .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (06) :2451-2459
[26]  
TIMERMAN AP, 1993, J BIOL CHEM, V268, P22992
[27]   ANGULAR RECONSTITUTION - A POSTERIORI ASSIGNMENT OF PROJECTION DIRECTIONS FOR 3-D RECONSTRUCTION [J].
VANHEEL, M .
ULTRAMICROSCOPY, 1987, 21 (02) :111-123
[28]  
VANHEEL M, 1992, SCANNING MICROSCOPY, V6, P23
[29]   LOCALIZATION OF CALMODULIN-BINDING SITES ON THE RYANODINE RECEPTOR FROM SKELETAL-MUSCLE BY ELECTRON-MICROSCOPY [J].
WAGENKNECHT, T ;
BERKOWITZ, J ;
GRASSUCCI, R ;
TIMERMAN, AP ;
FLEISCHER, S .
BIOPHYSICAL JOURNAL, 1994, 67 (06) :2286-2295
[30]   3-DIMENSIONAL ARCHITECTURE OF THE CALCIUM-CHANNEL FOOT STRUCTURE OF SARCOPLASMIC-RETICULUM [J].
WAGENKNECHT, T ;
GRASSUCCI, R ;
FRANK, J ;
SAITO, A ;
INUI, M ;
FLEISCHER, S .
NATURE, 1989, 338 (6211) :167-170
1234