3-DIMENSIONAL ARCHITECTURE OF THE SKELETAL-MUSCLE RYANODINE RECEPTOR

被引：43

作者：

WAGENKNECHT, T ^{[1
]}

RADERMACHER, M ^{[1
]}

机构：

[1] SUNY ALBANY,SCH PUBL HLTH,DEPT BIOMED SCI,ALBANY,NY

来源：

FEBS LETTERS | 1995年 / 369卷 / 01期

关键词：

RYANODINE RECEPTOR; CALCIUM RELEASE; CRYOELECTRON MICROSCOPY; 3-DIMENSIONAL RECONSTRUCTION; EXCITATION-CONTRACTION; MUSCLE; IMAGE PROCESSING;

D O I：

10.1016/0014-5793(95)00581-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent advances in determining the three-dimensional architecture of the skeletal muscle ryanodine receptor/calcium release channel (RyR) by cryo-electron microscopy and three-dimensional reconstruction are discussed, The tetrameric receptor is characterized by a large 4-fold symmetric cytoplasmic assembly that consists of many domains separated by solvent-containing crevices and holes, Experimental evidence suggests that at least one regulatory ligand, calmodulin, binds to sites on the cytoplasmic assembly that are at least 10 nanometers from the transmembrane channel.

引用

页码：43 / 46

页数：4

共 33 条

[1] STRUCTURAL EVIDENCE FOR DIRECT INTERACTION BETWEEN THE MOLECULAR-COMPONENTS OF THE TRANSVERSE TUBULE SARCOPLASMIC-RETICULUM JUNCTION IN SKELETAL-MUSCLE [J].