CHANGES IN BETA-ADRENERGIC RECEPTORS UNDER LONG-TERM APPLICATION OF RITODRINE IN PREGNANT-RAT MYOMETRIUM

被引:5
作者
KAWARABAYASHI, T
TSUKAMOTO, T
KANEKO, Y
IKEDA, M
SUGIMORI, H
SHIRAKAWA, K
机构
[1] SAGA UNIV,DEPT APPL BIOL SCI,BIOCHEM LAB,SAGA 840,JAPAN
[2] SAGA MED SCH,DEPT OBSTET & GYNECOL,SAGA 84001,JAPAN
关键词
MYOMETRIUM; RITODRINE; BETA-RECEPTOR DENSITY;
D O I
10.1159/000292683
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Changes in beta-adrenergic receptor density under long-term application of ritodrine were investigated using longitudinal muscle strips of day-21-pregnant-rat myometrium. Membrane (-)[H-3]dihydroalprenolol binding sites were increased by 3.1 X 10(-8) M ritodrine, with a maximum increase at 3.1 X 10(-7) M, followed by a gradual decrease at higher concentrations. Under long-term application of a lower dose (1.5 X 10(-7) M) of ritodrine, the number of the binding sites increased up to 20 min, then decreased to the control level and fluctuated after 90 min. These results suggest that at lower doses, ritodrine might activate adenylate cyclase, resulting in conformational changes in the receptors, and that receptor density might vary in parallel with cellular cAMP production under long-term application of ritodrine.
引用
收藏
页码:136 / 139
页数:4
相关论文
共 8 条