INHIBITION OF MYELOPEROXIDASE RELEASE FROM RAT POLYMORPHONUCLEAR LEUKOCYTES BY A SERIES OF AZACHALCONE DERIVATIVES

被引：30

作者：

EDWARDS, ML

STEMERICK, DM

SABOL, JS

DIEKEMA, KA

DINERSTEIN, RJ

机构：

[1] Marion Merrell Dow Research Institute, Cincinnati, Ohio 45215

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 25期

关键词：

D O I：

10.1021/jm00051a013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of azachalcones was evaluated for ability to affect secretion of myeloperoxidase by rat polymorphonuclear leukocytes stimulated by fMLP. The compounds were found to interfere with cellular uptake of extracellular calcium. Structure-activity relationships are discussed.

引用

页码：4357 / 4362

页数：6

共 33 条

[1]

ANDERSSON T, 1986, MOL PHARMACOL, V30, P437

[2]

ARIYAN ZS, 1961, J CHEM SOC, P2242

[3]

BAGGIOLINI M, 1987, PHARM INFLAMMATION

[4] 2'-SUBSTITUTED CHALCONE DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1 BIOSYNTHESIS [J].