1ST-TRIMESTER MATERNAL SERUM UNCONJUGATED ESTRIOL AND ALPHA-FETOPROTEIN IN FETAL DOWNS-SYNDROME

被引：15
作者：
CRANDALL, BF
GOLBUS, MS
GOLDBERG, JD
MATSUMOTO, M
机构：
[1] UNIV CALIF LOS ANGELES,DEPT PEDIAT,LOS ANGELES,CA 90024
[2] UNIV CALIF SAN FRANCISCO,DEPT OBSTET GYNECOL & REPROD SERV,SAN FRANCISCO,CA 94143
来源：
PRENATAL DIAGNOSIS | 1991年 / 11卷 / 06期
关键词：
MATERNAL SERUM; ALPHA-FETOPROTEIN; UNCONJUGATED ESTRIOL; DOWNS SYNDROME;
D O I：
10.1002/pd.1970110606
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Maternal sera (MS) taken from 1396 women prior to chorionic villus sampling at 9-12 menstrual weeks were assayed for unconjugated oestriol (uE3) and alpha-fetoprotein (AFP). Median levels increased by 41 and 26 per cent per week respectively in normal pregnancies. There were 32 pregnancies with a chromosome abnormality. The median MS uE3 and AFP were 0.73 and 0.75 multiples of the median (MoM) respectively in the ten cases of Down's syndrome (DS) but not decreased in the other abnormalities. These results suggest that both uE3 and AFP may be useful in identifying DS in the first trimester. Additional prospective studies are needed to confirm these findings.
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收藏
页码：377 / 380
页数：4
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