INVITRO AND INVIVO PRODUCTION OF INTERLEUKIN-6 BY FETAL MONONUCLEAR-CELLS

被引：36

作者：

MATSUZAKI, N ^{[1
]}

SAJI, F ^{[1
]}

KAMEDA, T ^{[1
]}

YOSHIZAKI, K ^{[1
]}

OKADA, T ^{[1
]}

SAWAI, K ^{[1
]}

TANIZAWA, O ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT INTERNAL MED 3,OSAKA 553,JAPAN

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1990年 / 55卷 / 02期

关键词：

D O I：

10.1016/0090-1229(90)90106-Z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined the functional activity of cord mononuclear cells (MNCs) to produce interleukin (IL)-6 in vitro and in vivo. We stimulated fetal T-cell, B-cell, and macrophage fractions with mitogens. The supernatant of each stimulated cord cell fraction contained a comparable amount of IL-6 to that of each adult cell fraction activated similarly, suggesting functional maturity of cord MNCs' ability to produce IL-6. We then examined fetal cells' activities to produce IL-6 in response to perinatal infections, especially to intraamniotic infections (IAI). Among the cord MNCs from fetuses with IAI, macrophages were major cells producing IL-6. The serum IL-6 level in the fetuses with IAI was elevated, but it decreased to normal levels after antibiotic treatment; this finding indicates that IL-6-mediated host defense mechanisms by cord MNCs are triggered by perinatal infections. © 1990.

引用

页码：305 / 314

页数：10

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