THE ENIGMA OF THE NATURAL-KILLER-CELL

被引：239
作者：
GUMPERZ, JE [1 ]
PARHAM, P [1 ]
机构：
[1] STANFORD UNIV, DEPT MICROBIOL & IMMUNOL, STANFORD, CA 94305 USA
来源：
NATURE | 1995年 / 378卷 / 6554期
关键词：
D O I：
10.1038/378245a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Natural killer (NK) cells are controlled by receptors specific for polymorphic determinants of class I molecules of the major histocompatibility complex (MHC). The contrasting properties of NK and cytotoxic T cell (CTL) class I receptors provide complementarity in the cytolytic lymphocyte response to viruses, tumours and transplants. Whereas human NK cell class I receptors consist of immunoglobulin domains, their mouse counterparts resemble C-type lectins. This difference may reflect the receptors' diverse and rapidly evolving class I ligands.
引用
收藏
页码：245 / 248
页数：4
相关论文
共 90 条
[1]  
ADAMKIEWICZ TV, 1994, IMMUNOGENETICS, V39, P218
[2]  
BARBER LD, 1993, ANNU REV CELL BIOL, V9, P163
[3]   IMMUNOLOGY - RESEARCHERS FIND MOLECULES THAT MUZZLE KILLER-CELLS [J].
BARINAGA, M .
SCIENCE, 1995, 268 (5209) :367-368
[4]  
BEZOUSKA K, 1994, J BIOL CHEM, V269, P16945
[5]   RETRACTED: OLIGOSACCHARIDE LIGANDS FOR NKR-P1 PROTEIN ACTIVATE NK CELLS AND CYTOTOXICITY (Retracted article. See vol. 500, pg. 492, 2013) [J].
BEZOUSKA, K ;
YUEN, CT ;
OBRIEN, J ;
CHILDS, RA ;
CHAI, WG ;
LAWSON, AM ;
DRBAL, K ;
FISEROVA, A ;
POSPISIL, M ;
FEIZI, T .
NATURE, 1994, 372 (6502) :150-157
[6]   REJECTION OF CLASS-I MHC-DEFICIENT HEMATOPOIETIC-CELLS BY IRRADIATED MHC-MATCHED MICE [J].
BIX, M ;
LIAO, NS ;
ZIJLSTRA, M ;
LORING, J ;
JAENISCH, R ;
RAULET, D .
NATURE, 1991, 349 (6307) :329-331
[7]   STRUCTURE, FUNCTION, AND DIVERSITY OF CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX-MOLECULES [J].
BJORKMAN, PJ ;
PARHAM, P .
ANNUAL REVIEW OF BIOCHEMISTRY, 1990, 59 :253-288
[8]   STRUCTURE OF THE HUMAN CLASS-I HISTOCOMPATIBILITY ANTIGEN, HLA-A2 [J].
BJORKMAN, PJ ;
SAPER, MA ;
SAMRAOUI, B ;
BENNETT, WS ;
STROMINGER, JL ;
WILEY, DC .
NATURE, 1987, 329 (6139) :506-512
[9]   EXPRESSION OF DIFFERENT MEMBERS OF THE LY-49 GENE FAMILY DEFINES DISTINCT NATURAL-KILLER-CELL SUBSETS AND CELL-ADHESION PROPERTIES [J].
BRENNAN, J ;
MAGER, D ;
JEFFERIES, W ;
TAKEI, F .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (06) :2287-2295
[10]   CRYSTAL-STRUCTURE OF THE COMPLEX OF RAT NEONATAL FC RECEPTOR WITH FC [J].
BURMEISTER, WP ;
HUBER, AH ;
BJORKMAN, PJ .
NATURE, 1994, 372 (6504) :379-383
123456789