PRACTICAL SYNTHESIS OF THE PUTATIVE POLYAMINE SPIDER TOXIN FTX - A PROPOSED BLOCKER OF VOLTAGE-SENSITIVE CALCIUM CHANNELS

被引：27

作者：

BLAGBROUGH, IS

MOYA, E

机构：

[1] Department of Medicinal Chemistry School of Pharmacy and Pharmacology, University of Bath, Bath, BA2 7AY, Claverton Down

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(00)73048-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

FTX (FTX-3.3), a putative polyamine toxin from American funnel-web spiders, has been synthesized from tri-CBZ-L-arginine. Raney nickel mediated desulfurization of a thioamide, generated selectively with Lawesson's reagent in the presence of the benzyloxycarbamates, allowed ready access to the S-enantiomer. The synthetic sample with the claimed structure for FTX-3.3 differs spectroscopically from the data published for the isolated toxin. The published structure requires a reappraisal of the spectroscopic data.

引用

页码：2057 / 2060

页数：4

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