INTERMOLECULAR DISPLACEMENT OF S-BOUND L-METHIONINE ON PLATINUM(II) BY GUANOSINE 5'-MONOPHOSPHATE - IMPLICATIONS FOR THE MECHANISM OF ACTION OF ANTICANCER DRUGS

被引：154

作者：

BARNHAM, KJ

DJURAN, MI

MURDOCH, PD

SADLER, PJ

机构：

[1] UNIV LONDON,BIRKBECK COLL,DEPT CHEM,GORDON HOUSE LAB,29 GORDON SQ,LONDON WC1H 0PP,ENGLAND

[2] UNIV LONDON,BIRKBECK COLL,DEPT CHEM,CHRISTOPHER INGOLD LAB,LONDON WC1H 0PP,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 06期

关键词：

D O I：

10.1039/c39940000721

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

NMR investigations of the kinetics and thermodynamics of the competitive binding of L-methionine (Met), L-histidine (His), and 5'-monophosphates of guanosine (5'-GMP), adenosine (5'-AMP), thymidine (5'-TMP) and cytidine (5'-CMP) to [Pt(dien)CI]+ (dien = 1,5-diamino-3-azapentane) in aqueous solution show that 5'-GMP selectively displaces S-bound Met, a finding which has implications for DNA platination by anticancer drugs in vivo.

引用

页码：721 / 722

页数：2

共 19 条

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