TOXIC HEALTH-EFFECTS INCLUDING REVERSIBLE MACROTHROMBOCYTOSIS IN WORKERS EXPOSED TO ASPHALT FUMES

被引：6

作者：

CHASE, RM ^{[1
]}

LISS, GM ^{[1
]}

COLE, DC ^{[1
]}

HEATH, B ^{[1
]}

机构：

[1] ONTARIO MINIST LABOR,HLTH & SAFETY STUDIES UNIT,TORONTO,ON,CANADA

来源：

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE | 1994年 / 25卷 / 02期

关键词：

BLOOD PLATELET DISORDERS; HEMATOLOGICAL PARAMETERS; OCCUPATIONAL EXPOSURE; ASPHALT; BENZENE; BIOLOGICAL EFFECT; FOLLOW-UP STUDIES;

D O I：

10.1002/ajim.4700250214

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We investigated an outbreak of irritative and neurotoxic symptoms associated with exposure to asphalt fumes in a commercial lighting factory; 27 symptomatic female workers were clinically assessed including hematologic testing. When compared with a laboratory reference group (n = 107), the workers' mean platelet volume (MPV) was significantly higher and mean platelet count was lower(p = 0.013 and p = 0.048, respectively). Five months later, the factory's ventilation system was substantially modified. Follow-up assessments 6 months postmodification on 15 of the original workers documented a significant decline in acute symptoms and a lowering of the subjects' mean MPV towards normal (p = 0.0007 by paired t-test). The findings suggest that reversible macrothrombocytosis (enlarged platelets) can occur among symptomatic workers exposed to asphalt fumes. (C) 1994 WiIey-Liss, Inc.

引用

页码：279 / 289

页数：11