A MUSCARINIC RECEPTOR AGONIST MOBILIZES CA-2+ FROM CAFFEINE AND INOSITOL-1,4,5-TRISPHOSPHATE-SENSITIVE CA-2+ STORES IN CAT ADRENAL CHROMAFFIN CELLS

被引：21
|
作者：
SORIMACHI, M
YAMAGAMI, K
NISHIMURA, S
机构：
[1] Department of Physiology, Kagoshima University, School of Medicine, Kagoshima
来源：
BRAIN RESEARCH | 1992年 / 571卷 / 01期
关键词：
CYTOSOLIC-FREE CALCIUM; FURA-2; MICROFLUORIMETRY; CAFFEINE; INOSITOL-1,4,5-TRISPHOSPHATE; ADRENAL CHROMAFFIN CELL; CAT;
D O I：
10.1016/0006-8993(92)90523-C
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To gain some understanding of the characteristics of intracellular Ca2+ stores of cat adrenal chromaffin cells, we investigated the effects of ryanodine, a blocker of Ca2+-induced Ca2+ release channels in muscle, on both cytosolic Ca2+ concentration and catecholamine secretion induced by caffeine or methacholine. The results suggest that Ca2+ stores consist of at least two compartments, one which is sensitive to both caffeine and inositol-1,4,5-trisphosphate (IP3), and the other which is sensitive to IP3 alone.
引用
收藏
页码：154 / 158
页数：5
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