INHIBITION OF ASPARTIC PROTEINASES BY PROPART PEPTIDES OF HUMAN PROCATHEPSIN-D AND CHICKEN PEPSINOGEN

被引：43

作者：

FUSEK, M ^{[1
]}

MARES, M ^{[1
]}

VAGNER, J ^{[1
]}

VOBURKA, Z ^{[1
]}

BAUDYS, M ^{[1
]}

机构：

[1] RES INST FEED SUPPLEMENTS & VET DRUGS, PRAGUE, CZECHOSLOVAKIA

来源：

FEBS LETTERS | 1991年 / 287卷 / 1-2期

关键词：

ASPARTIC PROTEINASE; PROPART PEPTIDE; HUMAN PROCATHEPSIN-D; CHICKEN PEPSINOGEN; INHIBITION; ZYMOGEN ACTIVATION;

D O I：

10.1016/0014-5793(91)80040-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two propart peptides of aspartic proteinases, the propart peptide of chicken pepsin and human cathepsin D, respectively, were investigated from the point of view of their inhibitory activity for a set of aspartic proteinases. These peptides display a very broad inhibitory spectrum. The strongest inhibition was observed for pepsin A-like proteinases where propart peptides can be used as titrants of active enzymes.

引用

页码：160 / 162

页数：3

共 16 条

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