USE OF GENE PROBES BASED ON THE INSERTION-SEQUENCE IS986 TO DIFFERENTIATE BETWEEN BCG VACCINE STRAINS

被引：60

作者：

FOMUKONG, NG

DALE, JW

OSBORN, TW

GRANGE, JM

机构：

[1] UNIV SURREY,SCH BIOL SCI,MOLEC MICROBIOL GRP,GUILDFORD GU2 5XH,SURREY,ENGLAND

[2] ROYAL BROMPTON HOSP,NATL HEART & LUNG INST,LONDON,ENGLAND

来源：

JOURNAL OF APPLIED BACTERIOLOGY | 1992年 / 72卷 / 02期

关键词：

D O I：

10.1111/j.1365-2672.1992.tb01813.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Gene probes derived from the insertion sequence IS986, which have previously been shown to differentiate isolates of Mycobacterium tuberculosis for epidemicological analysis, are also capable of distinguishing two groups of BCG vaccine strains. Most BCG strains have a single copy of IS986, at the same chromosomal site, while the Brazilian, Japanese and USSR strains have an additional copy at a different, common location. These results correlate with the results of previous antigenic analysis and may reflect a different clonal origin of the two groups of BCG strains.

引用

页码：126 / 133

页数：8

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