CHARACTERIZATION OF SILKWORM CHLOROPHYLL METABOLITES AS AN ACTIVE PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY

被引：32

作者：

DAI, R ^{[1
]}

SHOEMAKER, R ^{[1
]}

FARRENS, D ^{[1
]}

HAN, MJ ^{[1
]}

KIM, CS ^{[1
]}

SONG, PS ^{[1
]}

机构：

[1] UNIV NEBRASKA,DEPT CHEM,LINCOLN,NE 68588

来源：

JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 09期

关键词：

D O I：

10.1021/np50087a010

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Silkworm excreta containing chlorophyll metabolites have long been used for their medicinal activities in the Far East. The major chlorophyll derivative (CpD) fraction in the Me2CO extract from the silkworm excreta exhibits strong photodynamic action on mice and human rumor cells in vitro. The main CpD component was isolated, purified, and subjected to extensive structural and characterization studies to assess its photodynamic therapeutic activity. According to the spectral analyses, the structure of the major unknown CpD was determined to be 10-hydroxypheophytin a[1]. The CpD component possessed a high quantum efficiency (50%) for the photosensitized production of singlet molecular oxygen, thus providing a molecular basis for its photodynamic therapeutic efficiency. A further advantage is that the ''photooxidation/degradation'' product(s) from this CpD retains all the characteristics of a photodynamic sensitizer.

引用

页码：1241 / 1251

页数：11

共 34 条

[1] CHANGES IN CHLOROPHYLLS RESULTING FROM VARIOUS CHEMICAL AND PHYSICAL TREATMENTS OF LEAVES AND LEAF EXTRACTS [J].