THE PHARMACOKINETICS OF BETA-CYCLODEXTRIN AND HYDROXYPROPYL-BETA-CYCLODEXTRIN IN THE RAT

被引：101

作者：

FRIJLINK, HW ^{[1
]}

VISSER, J ^{[1
]}

HEFTING, NR ^{[1
]}

OOSTING, R ^{[1
]}

MEIJER, DKF ^{[1
]}

LERK, CF ^{[1
]}

机构：

[1] UNIV GRONINGEN,DEPT PHARMACOL & THERAPEUT,9713 AW GRONINGEN,NETHERLANDS

来源：

PHARMACEUTICAL RESEARCH | 1990年 / 7卷 / 12期

关键词：

absorption; hydroxypropyl-β-cyclodextrin; intravenous administration; oral administration; pharmacokinetics; β-cyclodextrin;

D O I：

10.1023/A:1015929720063

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydroxypropyl-β-cyclodextrin was analyzed by HPLC using postcolumn complexation with phenolphthalein and negative colorimetric detection, with a detection limit of 20 µg/ml. The pharmacokinetics of β-cyclodextrin and of hydroxypropyl-β-cyclodextrin were studied after intravenous administration to permanently cannulated rats. The pharmacokinetic behavior of both cyclodextrins was similar to that of inulin, showing rapid distribution over extracellular fluids. Elimination occurred through glomerular filtration. When a dose of 200 mg/kg β-cyclodextrin was administered the elimination rate was decreased, probably as a result of nephrotoxicity of β-cyclodextrin. Within 24 hr after administration most of the cyclodextrin dose was recovered unchanged in urine. After oral administration, only insignificant amounts of intact β-cyclodextrin were absorbed from the gastrointestinal tract. © 1990, Plenum Publishing Corporation. All rights reserved.

引用

页码：1248 / 1252

页数：5

共 26 条

[1] EFFECTS OF BETA-CYCLODEXTRINS AND GAMMA-CYCLODEXTRINS ON THE PHARMACOKINETIC BEHAVIOR OF PREDNISOLONE AFTER INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATIONS TO RABBITS [J].

ARIMORI, K ;

UEKAMA, K .

JOURNAL OF PHARMACOBIO-DYNAMICS, 1987, 10 (08) :390-395

[2] IMPROVED DELIVERY THROUGH BIOLOGICAL-MEMBRANES .31. SOLUBILIZATION AND STABILIZATION OF AN ESTRADIOL CHEMICAL DELIVERY SYSTEM BY MODIFIED BETA-CYCLODEXTRINS [J].

BREWSTER, ME ;

ESTES, KS ;

LOFTSSON, T ;

PERCHALSKI, R ;

DERENDORF, H ;

MULLERSMAN, G ;

BODOR, N .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1988, 77 (11) :981-985

[3] SEVERE HYPERVITAMINOSIS A IN SIBLINGS - EVIDENCE OF VARIABLE TOLERANCE TO RETINOL INTAKE [J].

CARPENTER, TO ;

PETTIFOR, JM ;

RUSSELL, RM ;

PITHA, J ;

MOBARHAN, S ;

OSSIP, MS ;

WAINER, S ;

ANAST, CS .

JOURNAL OF PEDIATRICS, 1987, 111 (04) :507-512

[4]

DUCHENE D, 1987, CYCLODEXTRINS THEIR, P211

[5]

FRANK DW, 1976, AM J PATHOL, V83, P367

[6] DETERMINATION OF CYCLODEXTRINS IN BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH NEGATIVE COLORIMETRIC DETECTION USING POSTCOLUMN COMPLEXATION WITH PHENOLPHTHALEIN [J].

FRIJLINK, HW ;

VISSER, J ;

DRENTH, BFH .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1987, 415 (02) :325-333

[7]

GERLOCZY A, 1985, ARZNEIMITTEL-FORSCH, V35-2, P1042

[8] A NEW METHOD FOR THE DETERMINATION OF INULIN IN PLASMA AND URINE [J].

HEYROVSKY, A .

CLINICA CHIMICA ACTA, 1956, 1 (05) :470-474

[9]

IRIE T, 1988, INT J PHARM, V43, P41

[10]

IRIE T, 1983, J PHARMACOBIO-DYNAM, V6, P790

← 1 2 3 →