Testosterone Replacement Therapy in Adolescents With Sickle Cell Disease Reverses Hypogonadism Without Promoting Priapism: A Case Report

被引：5

作者：

Morrison, Belinda F. ^{[1
]}

Madden, Wendy ^{[2
]}

Clato-Day, Stephanie ^{[3
]}

Gabay, Leslie ^{[3
]}

机构：

[1] Univ West Indies, Dept Surg, Kingston 7, Jamaica

[2] Univ West Indies, Sickle Cell Unit, Kingston 7, Jamaica

[3] Univ West Indies, Dept Paediat, Kingston 7, Jamaica

来源：

UROLOGY CASE REPORTS | 2015年 / 3卷 / 06期

关键词：

Testosterone; Sickle cell disease; Hypogonadism; Priapism;

D O I：

10.1016/j.eucr.2015.07.006

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Delayed puberty secondary to hypogonadism is commonly seen in sickle cell disease (SCD), affecting normal growth and development. The condition is rarely treated in SCD for fear of inducing priapism episodes. We present a case report of an Afro-Jamaican adolescent male at 16 years of age who presented with symptoms of delayed puberty as well as frequent stuttering priapism episodes. Endocrinological assessment revealed low serum total testosterone levels. Treatment was commenced monthly with testosterone enanthate which resulted in improved symptoms of delayed puberty, improvement in anthropometric parameters while apparently ameliorating priapism episodes. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.

引用

页码：179 / 180

页数：2

共 5 条

[1] Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism [J].