Histological, Immunohistological, and Clinical Features of Merkel Cell Carcinoma in Correlation to Merkel Cell Polyomavirus Status

被引：49
作者：
Jaeger, T. [1 ]
Ring, J. [1 ]
Andres, C. [1 ]
机构：
[1] Tech Univ Munich, Dept Dermatol & Allergy Biederstein, D-80802 Munich, Germany
来源：
JOURNAL OF SKIN CANCER | 2012年 / 2012卷
关键词：
D O I：
10.1155/2012/983421
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Merkel cell carcinoma is a rare, but highly malignant tumor of the skin with high rates of metastasis and poor survival. Its incidence rate rises and is currently about 0.6/100000/year. Clinical differential diagnoses include basal cell carcinoma, cyst, amelanotic melanoma, lymphoma and atypical fibroxanthoma. In this review article clinical, histopathological and immunhistochemical features of Merkel cell carcinoma are reported. In addition, the role of Merkel cell polyomavirus is discussed.
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