Diffuse large B-cell lymphoma: A metabolic disorder?

被引:8
作者
Tanios, Georges [1 ]
Aranguren, Ines M. [1 ]
Goldstein, Jack S. [1 ,2 ]
Patel, Chirag B. [1 ]
机构
[1] East Tennessee State Univ, James H Quillen Coll Med, Dept Internal Med, Johnson City, TN 37614 USA
[2] Mt Home VA Med Ctr, Dept Internal Med, Johnson City, IN USA
关键词
B-cell lymphoma; hypoglycemia; Non Hodgkins lymphoma; lactic acidosis; Warburg effect;
D O I
10.12659/AJCR.889580
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: B cell lymphoma constitutes 8085% of cases of Non Hodgkins lymphoma in the Untied States. Metabolic complications may arise from the disease itself or through its end organ involvement. Case Report: We describe a case of a diffuse large B cell lymphoma diagnosed by abdominal computed tomography after it initially presented as hypoglycemia not correctable by dextrose infusion that instead resulted in increased anion gap metabolic acidosis with elevated lactate levels. Conclusions: The case illustrates how lymphomas can present unusually with hypoglycemia and lactic acidosis, the latter being an ominous sign that can occur without liver involvement. In this regard, the case demonstrates the metabolic sequelae of lymphoma that should raise suspicion for an underlying process. This has implications for diagnosis, treatment, and patient survival. Attention should be paid especially in the primary care setting in order to minimize delays in diagnosis.
引用
收藏
页码:518 / 525
页数:8
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