SEQUENCES OF THE OXYTETRACYCLINE POLYKETIDE SYNTHASE-ENCODING OTC GENES FROM STREPTOMYCES-RIMOSUS

被引：42
作者：
KIM, ES
BIBB, MJ
BUTLER, MJ
HOPWOOD, DA
SHERMAN, DH
机构：
[1] UNIV MINNESOTA,DEPT MICROBIOL,ST PAUL,MN 55108
[2] UNIV MINNESOTA,INST BIOPROC TECHNOL,GORTNER LAB 240,ST PAUL,MN 55108
[3] JOHN INNES CTR,JOHN INNES INST,NORWICH NR4 7UH,NORFOLK,ENGLAND
[4] PFIZER LTD,SANDWICH CT13 9NJ,KENT,ENGLAND
来源：
GENE | 1994年 / 141卷 / 01期
关键词：
ANTIBIOTIC BIOSYNTHESIS; BETA-KETOACYL SYNTHASE; ACYL CARRIER PROTEIN; AMINO-ACID SIMILARITY;
D O I：
10.1016/0378-1119(94)90144-9
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The complete nucleotide sequences of the Streptomyces rimosus oxytetracycline (oxyTc) polyketide synthase (PKS)-encoding genes (otcY) has been determined, revealing three open reading frames. The deduced amino-acid sequences correspond to the presumed heterodimeric B-ketoacyl synthase and acyl carrier protein found in other type-II (multicomponent) PKS systems that specify construction of acetate-derived polyketide antibiotics.
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页码：141 / 142
页数：2
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