SV40 SMALL T-DELETION MUTANTS PREFERENTIALLY TRANSFORM MONONUCLEAR PHAGOCYTES AND LYMPHOCYTES-B INVIVO

被引：30

作者：

CICALA, C ^{[1
]}

POMPETTI, F ^{[1
]}

NGUYEN, P ^{[1
]}

DIXON, K ^{[1
]}

LEVINE, AS ^{[1
]}

CARBONE, M ^{[1
]}

机构：

[1] NICHHD,VIRUSES & CELLULAR BIOL SECT,BLDG 6A,ROOM 1A11,BETHESDA,MD 20892

来源：

VIROLOGY | 1992年 / 190卷 / 01期

关键词：

D O I：

10.1016/0042-6822(92)91237-O

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hamsters injected intracardiacally with wild-type SV40 developed diverse tumors, with no one type predominating. However, hamsters injected with small t deletion mutants of SV40 uniformly developed true histiocytic or B-cell lymphomas, both of which arise from rapidly dividing cell populations, with very few tumors of other types. Our results are consistent with in vitro studies which suggest a requirement for the small t function in SV40 transformation of nondividing cells. © 1992.

引用

页码：475 / 479

页数：5

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