INSULIN INDUCES PROGRESSIVE INSULIN RESISTANCE IN CULTURED RAT ADIPOCYTES - SEQUENTIAL EFFECTS AT RECEPTOR AND MULTIPLE POSTRECEPTOR SITES

被引:123
作者
GARVEY, WT
OLEFSKY, JM
MARSHALL, S
机构
关键词
D O I
10.2337/diabetes.35.3.258
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:258 / 267
页数:10
相关论文
共 50 条
[1]   INSULIN-INDUCED ALTERATIONS IN INSULIN BINDING AND INSULIN ACTION IN PRIMARY CULTURES OF RAT HEPATOCYTES [J].
AMATRUDA, JM ;
NEWMEYER, HW ;
CHANG, CL .
DIABETES, 1982, 31 (02) :145-148
[2]   HORMONAL-REGULATION OF PEPTIDE RECEPTORS AND TARGET-CELL RESPONSES [J].
CATT, KJ ;
HARWOOD, JP ;
AGUILERA, G ;
DUFAU, ML .
NATURE, 1979, 280 (5718) :109-116
[3]  
CHANG TH, 1978, J BIOL CHEM, V253, P4693
[4]   MECHANISM OF THE POSTRECEPTOR DEFECT IN INSULIN ACTION IN HUMAN OBESITY - DECREASE IN GLUCOSE-TRANSPORT SYSTEM ACTIVITY [J].
CIARALDI, TP ;
KOLTERMAN, OG ;
OLEFSKY, JM .
JOURNAL OF CLINICAL INVESTIGATION, 1981, 68 (04) :875-880
[5]   ROLE OF GLUCOSE-TRANSPORT IN THE POSTRECEPTOR DEFECT OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS [J].
CIARALDI, TP ;
KOLTERMAN, OG ;
SCARLETT, JA ;
KAO, M ;
OLEFSKY, JM .
DIABETES, 1982, 31 (11) :1016-1022
[6]  
CRETTAZ M, 1984, J BIOL CHEM, V259, P1543
[7]   INSULIN-RECEPTOR REGULATION AND DESENSITIZATION IN RAT HEPATOMA-CELLS - CONCOMITANT CHANGES IN RECEPTOR NUMBER AND IN BINDING-AFFINITY [J].
CRETTAZ, M ;
KAHN, CR .
DIABETES, 1984, 33 (05) :477-485
[8]  
FINK RI, 1983, J CLIN INVEST, V71, P1523, DOI 10.1172/JCI110908
[9]   RATE-LIMITING STEPS OF 2-DEOXYGLUCOSE UPTAKE IN RAT ADIPOCYTES [J].
FOLEY, JE ;
FOLEY, R ;
GLIEMANN, J .
BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 599 (02) :689-698
[10]   THE EFFECT OF INSULIN-TREATMENT ON INSULIN-SECRETION AND INSULIN ACTION IN TYPE-II DIABETES-MELLITUS [J].
GARVEY, WT ;
OLEFSKY, JM ;
GRIFFIN, J ;
HAMMAN, RF ;
KOLTERMAN, OG .
DIABETES, 1985, 34 (03) :222-234