TRANSCRIPTIONAL REGULATION OF BASIC FIBROBLAST GROWTH-FACTOR GENE-EXPRESSION IN CAPILLARY ENDOTHELIAL-CELLS

被引：54
作者：
WEICH, HA
IBERG, N
KLAGSBRUN, M
FOLKMAN, J
机构：
[1] CHILDRENS HOSP MED CTR, DEPT SURG, BOSTON, MA 02115 USA
[2] HARVARD UNIV, SCH MED, DEPT ANAT & CELLULAR BIOL, BOSTON, MA 02115 USA
[3] HARVARD UNIV, SCH MED, DEPT CHEM & MOLEC PHARMACOL, BOSTON, MA 02115 USA
来源：
JOURNAL OF CELLULAR BIOCHEMISTRY | 1991年 / 47卷 / 02期
关键词：
BFGF; CAPILLARY ENDOTHELIAL CELLS; TRANSCRIPTIONAL REGULATION; AUTOINDUCTION;
D O I：
10.1002/jcb.240470209
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The growth of capillary endothelial cells (BCE) is an important regulatory step in the formation of capillary blood vessels. In vivo, the proliferation of these cells is stringently controlled. In vitro they can be stimulated by polypeptide growth factors, such as acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF). Since bFGF is synthesized and stored by vascular endothelial cells, this mitogen may play an important role in an autocrine growth regulation during angiogenesis. Here, evidence is presented for induction of the mRNA of bFGF by bFGF itself. A similar increase of bFGF mRNA was observed in response to thrombin and after treatment with phorbol ester. These results suggest that an autocrine loop may exist that may serve to modulate the mitogenic response in BCE under various physiological conditions, (e.g., wound healing and new capillary formation).
引用
收藏
页码：158 / 164
页数：7
相关论文
共 42 条
[21]   AUTOCRINE STIMULATION OF INTRACELLULAR PDGF RECEPTORS IN V-SIS TRANSFORMED-CELLS [J].
KEATING, MT ;
WILLIAMS, LT .
SCIENCE, 1988, 239 (4842) :914-916
[22]   HEPARIN AFFINITY OF ANIONIC AND CATIONIC CAPILLARY ENDOTHELIAL CELL-GROWTH FACTORS - ANALYSIS OF HYPOTHALAMUS-DERIVED GROWTH-FACTORS AND FIBROBLAST GROWTH-FACTORS [J].
KLAGSBRUN, M ;
SHING, Y .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (03) :805-809
[23]   CLONING AND EXPRESSION OF CDNA-ENCODING HUMAN BASIC FIBROBLAST GROWTH-FACTOR [J].
KUROKAWA, T ;
SASADA, R ;
IWANE, M ;
IGARASHI, K .
FEBS LETTERS, 1987, 213 (01) :189-194
[24]   EXPRESSION OF A SET OF GROWTH-RELATED IMMEDIATE EARLY GENES IN BALB-C 3T3 CELLS - COORDINATE REGULATION WITH C-FOS OR C-MYC [J].
LAU, LF ;
NATHANS, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (05) :1182-1186
[25]   MONOCLONAL-ANTIBODIES AGAINST HEPARIN-BINDING GROWTH FACTOR-II BASIC FIBROBLAST GROWTH-FACTOR THAT BLOCK ITS BIOLOGICAL-ACTIVITY - INVALIDITY OF THE ANTIBODIES FOR TUMOR ANGIOGENESIS [J].
MATSUZAKI, K ;
YOSHITAKE, Y ;
MATUO, Y ;
SASAKI, H ;
NISHIKAWA, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (24) :9911-9915
[26]   BASIC FIBROBLAST GROWTH-FACTOR INDUCES ANGIOGENESIS INVITRO [J].
MONTESANO, R ;
VASSALLI, JD ;
BAIRD, A ;
GUILLEMIN, R ;
ORCI, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (19) :7297-7301
[27]   PURIFICATION OF A FACTOR FROM HUMAN-PLACENTA THAT STIMULATES CAPILLARY ENDOTHELIAL-CELL PROTEASE PRODUCTION, DNA-SYNTHESIS, AND MIGRATION [J].
MOSCATELLI, D ;
PRESTA, M ;
RIFKIN, DB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (07) :2091-2095
[28]   STUDIES AND PERSPECTIVES OF PROTEIN-KINASE-C [J].
NISHIZUKA, Y .
SCIENCE, 1986, 233 (4761) :305-312
[29]   POSSIBLE POSITIVE AUTOCRINE FEEDBACK IN THE PREREPLICATIVE PHASE OF HUMAN-FIBROBLASTS [J].
PAULSSON, Y ;
HAMMACHER, A ;
HELDIN, CH ;
WESTERMARK, B .
NATURE, 1987, 328 (6132) :715-717
[30]   BASIC FIBROBLAST GROWTH-FACTOR FUSED TO A SIGNAL PEPTIDE TRANSFORMS CELLS [J].
ROGELJ, S ;
WEINBERG, RA ;
FANNING, P ;
KLAGSBRUN, M .
NATURE, 1988, 331 (6152) :173-175
12345