OPIOID INVOLVEMENT IN THE ADAPTIVE CHANGE OF 5-HT1 RECEPTORS INDUCED BY CHRONIC RESTRAINT

被引：31

作者：

CANCELA, L

VOLOSIN, M

MOLINA, VA

机构：

[1] Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5016 Córdoba, Sucursal 16

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 176卷 / 03期

关键词：

(Adaptive change); 5-HT[!sub]1[!/sub] receptors; 5-MeODMT; (5-methoxy-N; N-dimethyltryptamine); Immobilization (chronic); Morphine; Naloxone; β-Endorphin;

D O I：

10.1016/0014-2999(90)90025-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rats immobilized for 2 h daily for 7 days showed an increased behavioral response (forepaw treading and hind-limb abduction) to 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) 24 h after the last stress session. An injection of naloxone before each stress session fully antagonized the increased behavioral reactivity to 5-MeODMT. Treatment with morphine or β-endorphin associated with each immobilization session for 3 days produced a response to 5-MeODMT higher than that of animals subjected to immobilization only. Chronic immobilization for 7 days did not affect the shaking behavior induced by 5-hydroxytryptophan (5-HTP) 24 h after the last restraint session. These findings suggest that chronic stress may induce a selective adaptive change of the 5-HT1 site and activate an opioid mechanism that is most likely to be involved in the development of this adaptive change. © 1990.

引用

页码：313 / 319

页数：7

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