EFFECT OF CHOLECYSTOKININ OCTAPEPTIDE ON ENDOGENOUS AMINO-ACID RELEASE FROM THE RAT VENTROMEDIAL NUCLEUS OF THE HYPOTHALAMUS AND STRIATUM

被引：28

作者：

BARNES, S ^{[1
]}

WHISTLER, HL ^{[1
]}

HUGHES, J ^{[1
]}

WOODRUFF, GN ^{[1
]}

HUNTER, JC ^{[1
]}

机构：

[1] ADDENBROOKES HOSP, PARKE DAVIS RES UNIT, HILLS RD, CAMBRIDGE CB2 2QQ, ENGLAND

来源：

JOURNAL OF NEUROCHEMISTRY | 1991年 / 56卷 / 04期

关键词：

CHOLECYSTOKININ; AMINO ACIDS; BRAIN SLICES; NEUROTRANSMITTER RELEASE; STRIATUM; VENTROMEDIAL NUCLEUS OF THE HYPOTHALAMUS;

D O I：

10.1111/j.1471-4159.1991.tb11439.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sulphated octapeptide of cholecystokinin (CCK-8S) was found to cause a dose-dependent increase in the basal release of asparate, glycine, and gamma-aminobutyric acid from the striatum and the ventromedial nucleus of the hypothalamus (VMH). No effect on amino acid release was observed after electrical (VMH) or potassium (striatum) stimulation. Experiments performed using the CCK(B)-selective antagonist L-365,260 and the CCK(A)-selective antagonist L-364,718 suggested that this action of CCK-8S was mediated via the CCK(B) receptor. The ability of CCK-8S to evoke amino acid release was not dependent on the presence of extracellular calcium, though the effect was abolished by tetrodotoxin. Inhibition of protein kinase activity by staurosporine prevented the excitatory effects of CCK-8S on amino acid release.

引用

页码：1409 / 1416

页数：8

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