Objectives: An Infertility medical, psychiatric, psychological, and social aspect of the psychic trauma is causing a crisis situation. Developments in reproduction techniques and patients with a direction of hope, especially in women dealing with sadness and loss of control, are creating situations such as stigma. In this study, women dealing with despair and hopelessness undergoing infertility treatment were examined for variables that may contribute to the symptoms, including self-esteem, dyadic adjustment, personality traits, and socio-demographics. Methods: The cross-sectional and descriptive nature of this research was granted by Ege University Medical Faculty Hospital. Patient history between 2009-2010was obtained from the Family Planning and the Infertility Research Center. The study sample consisted of 141 women. Data was collected using an Information Form, Beck Hopelessness Scale (BHS), Rosenberg Self-Esteem Scale (RSES), Dyadic Adjustment Scale (DAS), and the Temperament and Character Inventory (TCI). Results: The mean age was 32.21 (SD=4.73) and infertile women received a mean RSES score of 5.13 (SD=3.52). BHS scores were taken from the average of 7.52 (SD=3.82). Self-esteem for the women in this study group was 37.3% low, 45.6% moderate, and 17.9% higher, respectively. In low-income groups, the BHS scores was significantly lower (F=12.35, p<0.01). The arranged married women felt higher levels of hopelessness (F=3.63, p<0.05). The relationship between dyadic adjustment in women with negative moderate levels of hopelessness received an r value of-0.445 (p<0.01). Infertility treatment in women participating in the study period scored a higher BHS than the long ones (F=2.88, p<0.05). Women between the RSES and receive their scores from BHS significant positive correlation was found (r=0.445, p<0.01). According to the results of the regression analysis of responsibility, resourcefulness and self-forget -shaped feature three characters in women has been identified as predictors of hopelessness (F=16:36, p<0.01). Conclusion: The self-esteem in infertile women couples harmony and character traits are variables affecting despair. In the process of infertility treatment will be useful to include supportive psychosocial approaches.