CHARACTERIZATION OF AN EARLY ACTIVATION-DEPENDENT ANTIGEN ON LYMPHOCYTES DEFINED BY THE MONOCLONAL-ANTIBODY BL-AC(F2)

被引：65

作者：

EICHLER, W ^{[1
]}

AUST, G ^{[1
]}

HAMANN, D ^{[1
]}

机构：

[1] CITY HOSP LEIPZIG, LEIPZIG, GERMANY

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1994年 / 39卷 / 01期

关键词：

D O I：

10.1111/j.1365-3083.1994.tb03348.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A novel activation-dependent lymphocyte cell-surface antigen which is recognized by a MoAb, BL-Ac(F2), is described. Although not found on resting lymphocytes the antigen is induced rapidly within 2-4 h following stimulation of the cells using mitogens or antibodies against the T-cell CD3 antigen and sIgM on B cells, respectively. Immunoprecipitation and Western Blotting indicated that the MoAb recognizes a molecule in a range of 78-85 kDa. Beyond its activation-dependent expression on lymphocytes the antigen was detected also on myelo-monocytic cells. Expression kinetics and cellular distribution of this molecule suggest that it is distinct from previously described activation-dependent cell-surface antigens such as CD69, CD25 and 4F2.

引用

页码：111 / 115

页数：5

共 23 条

[1]

CARREL S, 1990, J IMMUNOL, V144, P2053

[2] SIMULTANEOUS FLOW CYTOMETRIC ANALYSIS OF HUMAN T-CELL ACTIVATION ANTIGEN EXPRESSION AND DNA CONTENT [J].