DNA-SEQUENCES AT IMMUNOGLOBULIN SWITCH REGION RECOMBINATION SITES

被引：238
作者：
DUNNICK, W
HERTZ, GZ
SCAPPINO, L
GRITZMACHER, C
机构：
[1] MED BIOL INST,LA JOLLA,CA
[2] SCRIPPS CLIN & RES FDN,LA JOLLA,CA 92037
[3] UNIV COLORADO,DEPT MOLEC CELLULAR & DEV BIOL,BOULDER,CO 80309
来源：
NUCLEIC ACIDS RESEARCH | 1993年 / 21卷 / 03期
关键词：
D O I：
10.1093/nar/21.3.365
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The immunoglobulin heavy chain switch from synthesis of IgM to IgG, IgA or IgE is mediated by a DNA recombination event. Recombination occurs within switch regions, 2 - 10 kb segments of DNA that lie upstream of heavy chain constant region genes. A compilation of DNA sequences at more than 150 recombination sites within heavy chain switch regions is presented. Switch recombination does not appear to occur by homologous recombination. An extensive search for a recognition motif failed to find such a sequence, implying that switch recombination is not a site-specific event. A model for switch recombination that involves illegitimate priming of one switch region on another, followed by error-prone DNA synthesis, is proposed.
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页码：365 / 372
页数：8
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