KINETIC-STUDY ON P-TYRAMINE METABOLISM IN HUMANS USING STABLE ISOTOPE-LABELED TRACERS

被引：1

作者：

SHIMAMURA, M ^{[1
]}

KODAKA, H ^{[1
]}

HAYASHI, T ^{[1
]}

NARUSE, H ^{[1
]}

机构：

[1] NATL INST NEUROSCI,KODAIRA,TOKYO 187,JAPAN

来源：

NEUROCHEMICAL RESEARCH | 1993年 / 18卷 / 06期

关键词：

P-TYRAMINE; GAS-CHROMATOGRAPHY MASS-SPECTROMETRY; STABLE ISOTOPE METABOLISM;

D O I：

10.1007/BF00966788

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A sensitive method for the determination of p-tyramine was developed using gas chromatography-chemical ionization mass spectrometry. This method was combined with a stable isotope tracer technique to study p-tyramine metabolism in humans. [H-2]5-Phenylalanine was administered orally to men (5 mg/kg) as a tracer and the amounts of [H-2]4-p-tyramine excreted into urine were determined at each hour. Excretion of [H-2]4-p-tyramine was maximal between 1 and 2 hours following administration, at about 15 ng/kg.h in healthy adult men. Possible application in the study of metabolic disorders in human was demonstrated.

引用

页码：727 / 730

页数：4

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