Pathophysiology of cardiovascular disease in diabetes mellitus

被引：51
作者：
Rodriguez-Araujo, Gerardo [1 ,2 ]
Nakagami, Hironori [3 ]
机构：
[1] ProSciento Inc, Clin Res Innovat, 855 3rd Ave,Suite 3340, Chula Vista, CA 91911 USA
[2] Univ Arkansas Med Sci, Grad Sch, Little Rock, AR 72205 USA
[3] Osaka Univ, Grad Sch Med, Dept Hlth Dev & Med, Osaka, Japan
来源：
CARDIOVASCULAR ENDOCRINOLOGY & METABOLISM | 2018年 / 7卷 / 01期
关键词：
atherosclerosis; cardiovascular disease; cell signaling; cholesterol toxicity; diabetes mellitus; dyslipidemia; epigenetics; glucose toxicity; inflammation; pathophysiology;
D O I：
10.1097/XCE.0000000000000141
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetes mellitus elicits cellular, epigenetic, and post-translational changes that directly or indirectly affect the biology of the vasculature and other metabolic systems resulting in the apparition of cardiovascular disease. In this review, we provide a current perspective on the most recent discoveries in this field, with particular focus on hyperglycemia-induced pathology in the cardiovascular system. We also provide perspective on the clinical importance of molecular targeting of cardiovascular and diabetes mellitus therapies to treat hyperglycemia, inflammation, thrombosis, dyslipidemia, atherosclerosis, and hypertension. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.
引用
收藏
页码：4 / 9
页数：6
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