Frontotemporal White Matter in Adolescents with, and at-Risk for, Bipolar Disorder

被引:11
作者
de Zwarte, Sonja M. C. [1 ]
Johnston, Jennifer A. Y. [1 ]
Lippard, Elizabeth T. Cox [1 ]
Blumberg, Hilary P. [1 ,2 ,3 ]
机构
[1] Yale Sch Med, Dept Psychiat, 300 George St,Suite 901, New Haven, CT 06511 USA
[2] Yale Sch Med, Dept Diagnost Radiol, New Haven, CT 06511 USA
[3] Yale Sch Med, Ctr Child Study, New Haven, CT 06511 USA
来源
JOURNAL OF CLINICAL MEDICINE | 2014年 / 3卷 / 01期
关键词
bipolar disorder; frontal lobe; white matter; development; adolescents; diffusion tensor imaging;
D O I
10.3390/jcm3010233
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Frontotemporal neural systems are highly implicated in the emotional dysregulation characteristic of bipolar disorder (BD). Convergent genetic, postmortem, behavioral and neuroimaging evidence suggests abnormalities in the development of frontotemporal white matter (WM) in the pathophysiology of BD. This review discusses evidence for the involvement of abnormal WM development in BD during adolescence, with a focus on frontotemporal WM. Findings from diffusion tensor imaging (DTI) studies in adults and adolescents are reviewed to explore possible progressive WM abnormalities in the disorder. Intra- and interhemispheric frontotemporal abnormalities were reported in adults with BD. Although evidence in children and adolescents with BD to date has been limited, similar intrahemispheric and interhemispheric findings have also been reported. The findings in youths suggest that these abnormalities may represent a trait marker present early in the course of BD. Functional connectivity studies, demonstrating a relationship between WM abnormalities and frontotemporal dysfunction in BD, and DTI studies of vulnerability in first-degree relatives of individuals with BD, are discussed. Together, findings suggest the involvement of abnormal frontotemporal WM development in the pathophysiology of BD and that these abnormalities may be early trait markers of vulnerability; however, more studies are critically needed.
引用
收藏
页码:233 / 254
页数:22
相关论文
共 144 条
[31]   Abnormal corpus callosum myelination in pediatric bipolar patients [J].
Caetano, Sheila C. ;
Silveira, Camila Magalhaes ;
Kaur, Simerjit ;
Nicoletti, Mark ;
Hatch, John P. ;
Brambilla, Paolo ;
Sassi, Roberto ;
Axelson, David ;
Keshavan, Matcheri S. ;
Ryan, Neal D. ;
Birmaher, Boris ;
Soares, Jair C. .
JOURNAL OF AFFECTIVE DISORDERS, 2008, 108 (03) :297-301
[32]   The association of white matter volume in psychotic disorders with genotypic variation in NRG1, MOG and CNP: a voxel-based analysis in affected individuals and their unaffected relatives [J].
Cannon, D. M. ;
Walshe, M. ;
Dempster, E. ;
Collier, D. A. ;
Marshall, N. ;
Bramon, E. ;
Murray, R. M. ;
McDonald, C. .
TRANSLATIONAL PSYCHIATRY, 2012, 2 :e167-e167
[33]   THE CONFUSION BETWEEN BIPOLAR DISORDER AND SCHIZOPHRENIA IN YOUTH - WHERE DOES IT STAND IN THE 1990S [J].
CARLSON, GA ;
FENNIG, S ;
BROMET, EJ .
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1994, 33 (04) :453-460
[34]   White matter microstructural impairments and genetic liability to familial bipolar I disorder [J].
Chaddock, Christopher A. ;
Barker, Gareth J. ;
Marshall, Nicolette ;
Schulze, Katja ;
Hall, Mei Hua ;
Fern, Adele ;
Walshe, Muriel ;
Bramon, Elvira ;
Chitnis, Xavier A. ;
Murray, Robin ;
McDonald, Colm .
BRITISH JOURNAL OF PSYCHIATRY, 2009, 194 (06) :527-534
[35]   Cortical and subcortical white matter abnormalities in adults with remitted first-episode mania revealed by Tract-Based Spatial Statistics [J].
Chan, Wai-Yen ;
Yang, Guo-Liang ;
Chia, Ming-Ying ;
Woon, Puay-San ;
Lee, Jimmy ;
Keefe, Richard ;
Sitoh, Yih-Yian ;
Nowinski, Wieslaw Lucjan ;
Sim, Kang .
BIPOLAR DISORDERS, 2010, 12 (04) :383-389
[36]   Cortical magnetic resonance imaging findings in familial pediatric bipolar disorder [J].
Chang, K ;
Barnea-Goraly, N ;
Karchemskiy, A ;
Simeonova, DI ;
Barnes, P ;
Ketter, T ;
Reiss, AL .
BIOLOGICAL PSYCHIATRY, 2005, 58 (03) :197-203
[37]   Lifetime rates of suicide attempts among subjects with bipolar and unipolar disorders relative to subjects with other axis I disorders [J].
Chen, YW ;
Dilsaver, SC .
BIOLOGICAL PSYCHIATRY, 1996, 39 (10) :896-899
[38]   Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder [J].
Chepenik, Lara G. ;
Raffo, Mariella ;
Hampson, Michelle ;
Lacadie, Cheryl ;
Wang, Fei ;
Jones, Monique M. ;
Pittman, Brian ;
Skudlarski, Pawel ;
Blumberg, Hilary P. .
PSYCHIATRY RESEARCH-NEUROIMAGING, 2010, 182 (03) :207-210
[39]   Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia [J].
Corfas, G ;
Roy, K ;
Buxbaum, J .
NATURE NEUROSCIENCE, 2004, 7 (06) :575-580
[40]   Normal brain development and aging: Quantitative analysis at in vivo MR imaging in healthy volunteers [J].
Courchesne, E ;
Chisum, HJ ;
Townsend, J ;
Cowles, A ;
Covington, J ;
Egaas, B ;
Harwood, M ;
Hinds, S ;
Press, GA .
RADIOLOGY, 2000, 216 (03) :672-682