PROTECTIVE EFFECT OF LACTOFERRIN ON CERULEIN-INDUCED ACUTE-PANCREATITIS IN RATS

被引：5
|
作者：
KOIKE, D
MAKINO, I
机构：
[1] Second Department of Internal Medici, Asahikawa Medical College, Nishikagura 4-5-3-11, Asahikawa
来源：
DIGESTION | 1993年 / 54卷 / 02期
关键词：
LACTOFERRIN; CERULEIN; PANCREATITIS; EXPERIMENTAL; IRON;
D O I：
10.1159/000201018
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
In rats we studied the effects of lactoferrin on experimental acute pancreatitis caused by a single subcutaneous injection of 100 mug/kg body weight of caerulein. Lactoferrin isolated from human milk was given intraperitoneally to rats immediately after the injection of caerulein. The injection of 100 mg/kg body weight of lactoferrin significantly reduced the elevation in the serum amylase level and pancreatic wet weight; histological alterations of the pancreas were markedly suppressed. These results suggested that lactoferrin had a protective effect on the biochemical and histological alterations in this model.
引用
收藏
页码：84 / 90
页数：7
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