PROTECTIVE EFFECT OF LACTOFERRIN ON CERULEIN-INDUCED ACUTE-PANCREATITIS IN RATS

被引：5

作者：

KOIKE, D

MAKINO, I

机构：

[1] Second Department of Internal Medici, Asahikawa Medical College, Nishikagura 4-5-3-11, Asahikawa

来源：

DIGESTION | 1993年 / 54卷 / 02期

关键词：

LACTOFERRIN; CERULEIN; PANCREATITIS; EXPERIMENTAL; IRON;

D O I：

10.1159/000201018

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In rats we studied the effects of lactoferrin on experimental acute pancreatitis caused by a single subcutaneous injection of 100 mug/kg body weight of caerulein. Lactoferrin isolated from human milk was given intraperitoneally to rats immediately after the injection of caerulein. The injection of 100 mg/kg body weight of lactoferrin significantly reduced the elevation in the serum amylase level and pancreatic wet weight; histological alterations of the pancreas were markedly suppressed. These results suggested that lactoferrin had a protective effect on the biochemical and histological alterations in this model.

引用

页码：84 / 90

页数：7

共 29 条

[1] SUPEROXIDE-DEPENDENT AND ASCORBATE-DEPENDENT FORMATION OF HYDROXYL RADICALS FROM HYDROGEN-PEROXIDE IN THE PRESENCE OF IRON - ARE LACTOFERRIN AND TRANSFERRIN PROMOTERS OF HYDROXYL-RADICAL GENERATION [J].