THE PREPARATION AND CHARACTERIZATION OF POLY(LACTIDE-CO-GLYCOLIDE) MICROPARTICLES .1. OIL-IN-WATER EMULSION SOLVENT EVAPORATION

被引：177
作者：
JEFFERY, H
DAVIS, SS
OHAGAN, DT
机构：
[1] Department of Pharmaceutical Sciences, University of Nottingham, Nottingham
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 77卷 / 2-3期
基金：
英国医学研究理事会;
关键词：
POLY(LACTIDE-CO-GLYCOLIDE); BIODEGRADABLE MICROPARTICLES; SOLVENT EVAPORATION; OIL-IN-WATER EMULSION;
D O I：
10.1016/0378-5173(91)90314-E
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
An oil-in-water emulsion solvent evaporation technique has been used to prepare poly(lactide-co-glycolide) (PLGA) microparticles and the effect of various process parameters on particle size has been investigated. Particles of below 3-mu-m mean particle size were prepared by using a relatively small amount of polymer, a high stirring rate and a low volume of aqueous phase containing a high concentration of surfactant.
引用
收藏
页码：169 / 175
页数：7
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