3(2H)-ISOQUINOLINONES AND THEIR SATURATED DERIVATIVES

This chapter focuses on the 3(2H)-Isoquinolinones and their saturated derivatives. The name 3(2H)-isoquinolinones is used for the lactam structure to emphasize the connection with derivatives saturated in the hetero ring or in the aromatic ring of the isoquinolinone skeleton or both. One of the most widespread methods of synthesizing 3(2H)-isoquinolinones is the cyclization of esters of o-acyl-phenylacetic acids with appropriate amines. 1, 4-Dihydro-3(2H)-isoquinolinones are structural isomers of the well-known dihydrocarbostyril and dihydroisocarbostyril nitrogen heterocycles. The chapter discusses 5, 6, 7,8-Tetrahydro-3(2H)-isoquinolinones. Several derivatives of the unsaturated and saturated lactams mentioned in the chapter have been submitted to pharmacological investigations, and various biological activities were found. An attempt is made to enumerate some derivatives together with their biological properties. Such compounds are shown in the lactam structure. © 1991 Academic Press Inc.